Evidence map›Paper›PMID 41139435›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[Elevated expressions of GRP78/CHOP in lupus nephritis: their diagnostic value and association with PERK/IRE1α pathway-mediated renal cell apoptosis].

Yihan Wang, Weiqing Zhang, Ting Fang, Zhimin Xie, Yongsheng Fan, Xinchang Wang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Yihan WangSecond Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310015, China.
Weiqing ZhangSecond Clinical School of Zhejiang Chinese Medical University, Hangzhou 310053, China.
Ting FangSecond Clinical School of Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhimin XieSecond Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310015, China.
Yongsheng FanSecond Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310015, China.
Xinchang WangSecond Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310015, China.

Funding

National Natural Science Foundation Project 82374402
6 · The paper itself

Abstract

objectivesTo examine the changes in serum levels of endoplasmic reticulum stress (ERS) proteins GRP78/CHOP in patients with lupus nephritis (LN) and analyze their diagnostic value and association with renal pathological features.

methodsFrom a sample bank established based on a multicenter cohort study of systemic lupus erythematosus (SLE), 60 LN patients and 35 SLE patients without renal involvement were randomly selected. ELISA was used to detect serum levels of GRP78 and CHOP in the patients to analyze their correlation with clinical features and their diagnostic ability for LN and active LN. MRL/lpr mice were used as an animal model of LN to examine their serum levels of GRP78 and CHOP expression and renal expressions of endoplasmic reticulum apoptosis-related proteins.

resultsSerum GRP78 and CHOP levels were significantly higher in LN patients than in SLE patients without renal involvement (

conclusionsSerum levels of GRP78/CHOP are increased in LN patients possibly in association with ERS-induced apoptosis mediated by the PERK/IRE1α dual pathway.

Indexed as

ApoptosisHeat-Shock ProteinsLupus NephritisTranscription Factor CHOPAdultAnimalseIF-2 KinaseEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEndoribonucleasesFemaleHumansKidneyMaleMiceMice, Inbred MRL lprDDIT3 protein, humanDdit3 protein, mouseEIF2AK3 protein, humaneIF-2 KinaseEndoplasmic Reticulum Chaperone BiPEndoribonucleasesERN1 protein, humanHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseProtein Serine-Threonine KinasesTranscription Factor CHOPapoptosisCHOPendoplasmic reticulum stress pathwayGRP78lupus nephritisPERK/IRE1α

Identifiers

PMID41139435
PMCPMC12568467

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