Evidence map›Paper›PMID 41139428›Full record

Trial reportPsychogeriatrics : the official journal of the Japanese Psychogeriatric Society2025

Effectiveness of Individual Cognitive Stimulation on Cognition in Mild Alzheimer's Disease: A Multicenter RCT.

Susana I Justo-Henriques, Raquel Lemos, Pardis Rahmatpour, Rosa C G Silva, Janessa O Carvalho, Oscar Ribeiro

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05433493 (Effect of Individual Cognitive Stimulation on Memory and Executive Functioning in Older Adults With Mild to Moderate Alzheimer's Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05433493 nacompletednot on this map

Effect of Individual Cognitive Stimulation on Memory and Executive Functioning in Older Adults With Mild to Moderate Alzheimer's Disease: A Multicentre Randomised Controlled Trial

TypeinterventionalSponsorRsocialform - Geriatria, LdaRan2022 to 2023Enrolled142ConditionsDementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive DysfunctionArmsCognitive stimulation
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effectiveness of Individual Cognitive Stimulation on Cognition in Mild Alzheimer's Disease: A Multicenter RCT.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Susana I Justo-HenriquesPolytechnic Institute of Beja, Beja, Portugal.ORCID https://orcid.org/0000-0002-8872-4307
Raquel LemosChampalimaud Research & Clinical Centre, Champalimaud Foundation, Lisbon, Portugal.ORCID https://orcid.org/0000-0003-1221-915X
Pardis RahmatpourHealth Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0003-4271-8101
Rosa C G SilvaHealth Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0002-3947-7098
Janessa O CarvalhoDepartment of Psychology, Bridgewater State University, Bridgewater, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2948-9973
Oscar RibeiroRISE-Health, Department of Education and Psychology, University of Aveiro, Aveiro, Portugal.ORCID https://orcid.org/0000-0003-4740-7951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's Disease (AD) is characterised by impairments across several neurocognitive domains, including memory and executive function. The study explored the effectiveness of a 3-month individual Cognitive Stimulation (iCS) program in older adults with mild AD.

methodsA multicenter randomised controlled trial was conducted with 62 Portuguese older adults with mild AD. Participants were randomly assigned to either iCS (n = 33; 53%) or treatment as usual (TAU, n = 29; 47%). Cognitive outcomes were assessed at baseline, post-intervention, and 12-week follow-up using standardised tests for global cognition, memory and executive function.

resultsThe iCS group showed a significant improvement in memory and executive function compared to the TAU group. The analysis of subscales revealed significant improvements in encoding and semantic memory (Memory Alteration Test) and free delayed recall (Free and Cued Selective Reminding Test). Adherence and engagement with the intervention were high.

conclusionsA 3-month iCS program showed preliminary benefits in specific cognitive domains (memory and executive function) in older adults with mild AD, warranting further research with larger samples and longer follow-up. TRAIL REGISTRATION: Clinicaltrials.gov ID: NCT05433493; Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's Disease.

Indexed as

Alzheimer DiseaseCognitionCognitive Behavioral TherapyCognitive DysfunctionExecutive FunctionAgedAged, 80 and overFemaleHumansMaleMemoryNeuropsychological TestsPortugalTreatment OutcomeAlzheimer's diseasecognitive functioncognitive stimulationexecutive functionmemoryolder adults

Identifiers

PMID41139428
PMCPMC12554431

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.