SynthesisJournal of neurology2025
Late Lyme neuroborreliosis encephalomyelitis with distinct MRI features-a case report and systematic literature review.
Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lyme Neuroborreliosis With Acute Encephalopathy Despite Early Antibiotic Therapy: A Case Report.The American journal of case reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral nervous system (CNS) Lyme neuroborreliosis (LNB) rarely occurs. Clinical and radiological findings are heterogenous and considered unspecific, often delaying the time to diagnosis and treatment. Recently, specific clinical courses and MRI patterns have been proposed for patients presenting with brainstem encephalitis, but their relevance remains unclear.
objectiveTo describe radio-clinical features of patients with CNS-LNB encephalomyelitis, and to further investigate potential specific imaging patterns that could facilitate the diagnosis.
methodsWe report a case of late LNB encephalomyelitis with MRI findings compatible with a recently suggested distinct pattern. We provide a systematic review conducted using Embase and PubMed databases. The clinical, radiological and CSF features, as well as treatment outcome are reported.
resultsThirty-six cases of confirmed LNB encephalomyelitis were analyzed. The median time to diagnosis was 3 months. One third of patients had a history of tick bite. Common symptoms and signs included gait disorder (74%), headache (71%), fatigue (48%), muscle wasting (48%), and brainstem signs (45%). Common MRI findings were symmetric pontomesencephalic lesions (56%) with patterns compatible with Tarsier-sign (19%) and/or M-sign (33%), and leptomeningeal basal and/or perimedullary enhancement (31%). Twenty-eight percent of the patients recovered completely after treatment, while the remaining had mild neurological deficits (mRS 1-2).
conclusionsLeptomeningeal basal and perimedullary enhancement, along with pontomesencephalic symmetric lesions-sometimes compatible with Tarsier-sign and M-sign-could serve as potential MRI markers suggestive of CNS late LNB encephalomyelitis, aiding in earlier diagnosis and treatment.
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