Evidence map›Paper›PMID 41139325›Full record

ArticleJACC. Basic to translational science2026

Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids.

Gopika SenthilKumar, Zachary Zirgibel, Maria J Jaramillo-Torres, Rachel H Limpert, Katie E Cohen, Carolyn Shult, Brian Lindemer, Henry Bordas-Murphy, Callisia N Clarke, Julie K Freed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gopika SenthilKumarDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Zachary ZirgibelDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Maria J Jaramillo-TorresDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rachel H LimpertDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Katie E CohenCardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Carolyn ShultDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Brian LindemerDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Henry Bordas-MurphyDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Callisia N ClarkeDivision of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Julie K FreedDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: jfreed@mcw.edu.

Funding

Dual Functionality of Ceramide in Human Microvascular Endothelial FunctionR01HL160752 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Julie K Freed · 2022 to 2026
$3.1M
NHLBI NIH HHS R01 HL160752
6 · The paper itself

Abstract

Microvascular endothelial dysfunction strongly predicts poor cardiovascular outcomes, and recent studies have indicated that chronic estrogen treatment promotes endothelial dysfunction in isolated human microvessels. Here, using a translational approach, we demonstrate that sphingolipids are a critical component of estrogen signaling within the human microvascular endothelium. We provide evidence that the stark differences in how estrogen influences the microvascular endothelium are both time- and sex-dependent. This work adds mechanistic insight regarding the complexity and often contradictory relationship between estrogen and cardiovascular risk in humans.

Indexed as

ceramideendothelial dysfunctionestrogenmicrovasculature

Identifiers

PMID41139325
PMCPMC12902239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.