Evidence map›Paper›PMID 41139313›Full record

ArticleBriefings in bioinformatics2025

Spatial transcriptomics: a bibliometric analysis with large language model on English literatures.

Huiyang Li, Haixiao Wu, Wenjuan Ma, Shu Li, Jun Cai, Yile Lin, Jin Zhang, Yingmei Wang, Chao Zhang

Registry-linked trialAbstract read
In one paragraph

Article in Briefings in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07626606 (Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07626606 recruitingnot on this mapstarted 2026, after this paper: background citation

Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy

TypeobservationalSponsorCentre for Infectious Disease Research in ZambiaRan2026 to 2026Enrolled43ConditionsFeasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, TranscriptomicsArmsRotarix®,
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huiyang LiDepartment of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.
Haixiao WuDepartment of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wenjuan MaDepartment of Breast Imaging, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Shu LiDepartment of Public Service Management, School of Management, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jun CaiDepartment of Cancer Pharmacology, Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin Medicine and Health Research Center, Tianjin, China.
Yile LinI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Jin ZhangDepartment of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Yingmei WangDepartment of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.
Chao ZhangDepartment of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.ORCID 0000-0001-7096-8488

Funding

Key Laboratory of Tumor Immunology and PathologyMinistry of Education 2023jsz905Natural Science Foundation of China 72304207Natural Science Foundation of China 82011530050Natural Science Foundation of China 82304797Natural Science Foundation of Tianjin Municipal Science and Technology Commission 23JCQNJC00600New Teachers' Research Program of TUTCM XJS2022101Science & Technology Development Fund of Tianjin Education Commission for Higher Education 2022KJ156The Natural Science Foundation of Tianjin 25JCZDJC00700
6 · The paper itself

Abstract

Spatial transcriptomics (ST) integrates spatial data with transcriptomic information, providing high-resolution maps of gene expression within tissue contexts. It has revolutionized studies on cellular function and disease mechanisms, particularly in cancer and immunology. We conducted a bibliometric analysis of 1197 publications from the Web of Science (2015-24), focusing on publication trends, journal distribution, and keyword analysis to identify key research areas in ST. ST publications surged from 2021, with 500 papers in 2023. Five of the top 10 journals are from the Nature Publishing Group. Keyword analysis identified emerging trends like "tumor microenvironment," "immune infiltration," and "biomarker," highlighting ST's expanding role in cancer and immunology. International collaboration among multidisciplinary teams is crucial for maximizing ST's potential, and understanding its trends will guide its future impact. Large language models can further enrich the results of bibliometric research, making the findings of bibliometrics more comprehensive and specific.

Indexed as

BibliometricsLarge Language ModelsSpatial TranscriptomicsDrug DevelopmentGene Expression Regulation, NeoplasticHumansNeoplasmsNeurosciencesSurgical OncologyTranscriptomeTumor EscapeTumor Microenvironmentbibliometric analysisspatial transcriptomicstranscriptomicstumor microenvironment

Identifiers

PMID41139313
PMCPMC12554094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.