Evidence map›Paper›PMID 41139228›Full record

ArticleCancer2025

County-level medical debt and treatment initiation among individuals newly diagnosed with cancer.

Jingxuan Zhao, Marcelo Perraillon, Roxanne M Clark, Samuel J Greenwald, Daniel A Pollyea, Xuesong Han, K Robin Yabroff, Cathy J Bradley, Helen M Parsons

Abstract read
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingxuan ZhaoSurveillance, Prevention, and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2733-2000
Marcelo PerraillonColorado School of Public Health, University of Colorado Comprehensive Cancer Center, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0003-3355-3720
Roxanne M ClarkSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Samuel J GreenwaldSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Daniel A PollyeaDivision of Hematology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Xuesong HanSurveillance, Prevention, and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-7159-7949
K Robin YabroffSurveillance, Prevention, and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0644-5572
Cathy J BradleyColorado School of Public Health, University of Colorado Comprehensive Cancer Center, Aurora, Colorado, USA.
Helen M ParsonsSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-3822-9858

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Health Insurance and Disparities: More than AccessR01CA288259 · NCI · UNIVERSITY OF COLORADO DENVER · PI Cathy J Bradley, Marcelo Coca Perraillon · 2025 to 2026
$885k
Leukemia and Lymphoma Society, Grant/Award Number: HSR9027-24NCI NIH HHS P30 CA046934NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA288259
6 · The paper itself

Abstract

backgroundThe high costs of cancer care may lead to medical debt for patients and families. This study examined the association of county-level medical debt and timely treatment initiation among individuals newly diagnosed with cancer.

methodsIndividuals aged 19 years and older who were newly diagnosed with acute leukemias, diffuse large B-cell lymphoma, Hodgkin lymphoma, female breast cancer, colorectal cancer, and lung cancer with consecutive enrollment in the same insurance type from the month of diagnosis through 90 days afterward were identified from the 2012-2021 Colorado Central Cancer Registry linked to the Colorado All-Payer Claims Database with information about county-level medical debt from the Urban Institute (N = 35,789). The exposure was the county-level share of adults with medical debt in collections, categorized in four quartiles (Q1-Q4). The outcome was timely treatment initiation-defined as the receipt of any cancer-directed treatment within 90 days after cancer diagnosis. The association of county-level medical debt and time to treatment initiation was examined by using multivariable Cox models.

resultsHigher county-level medical debt was associated with lower likelihood of timely treatment initiation for all selected cancers combined (Q4 [counties with the highest medical debt rate; n = 8652] vs. Q1 [counties with the lowest medical debt rate; n = 9042]: hazard ratio [HR], 0.916; 95% confidence interval [CI], 0.871-0.963; p for trend = .001), for female breast cancer (Q4 vs. Q1: HR, 0.910; 95% CI, 0.847-0.978; p for trend = .011), and among individuals aged 19-64 years with private health maintenance organization plans (Q4 vs. Q1: HR, 0.790; 95% CI, 0.699-0.893; p for trend = .002) or Medicaid coverage (Q4 vs. Q1: HR, 0.869; 95% CI, 0.786-0.960; p for trend = .013).

conclusionsPolicies aimed at preventing and alleviating medical debt could be effective strategies for improving access to timely treatment.

Indexed as

NeoplasmsTime-to-TreatmentAdultAgedColoradoFemaleHumansMaleMedical DebtMiddle AgedRegistriesUnited StatesYoung Adultaccess to carehealth insurancemedical debtneoplasmstreatment delay

Identifiers

PMID41139228
PMCPMC13393554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.