ArticleAnnals of surgical oncology2026
Evaluating the Gail Model: Racial Disparities in Breast Cancer Risk Assessment.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Gail Model, a breast cancer risk calculator initially developed using data from primarily White women, has undergone recalibration using more diverse populations. However, concerns remain that risk is underestimated for certain racial groups.
methodsThis retrospective study evaluated the Gail Model's performance across different racial groups. Electronic medical record data from 31,256 women aged 25-75 who underwent mammograms between July 2020 and June 2023 were collected. The cohort included 11,589 Black/African American, 11,008 White, 5,872 Hispanic/Latino, 1,429 Asian, and 1,358 individuals identifying as other.
resultsSignificant differences in high-risk (HR) classification based on Gail scores were observed across racial groups. High-risk classification was highest among White women at 11.4%. Black compared with White women had an odds ratio (OR) 0.23 (95% confidence interval [CI] = 0.2-0.28) of HR classification. This difference persisted when controlling for all other variables. Breast cancer diagnosis rates were similar between Black (1.57%) and White women (1.6%).
conclusionsThese findings indicate a racial disparity in HR classification using the Gail Model. Black women are less likely to be identified as HR despite having comparable rates of cancer to White women. These results highlight the potential limitations of risk assessment algorithms incorporating race as a variable.
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