ArticleNpj viruses2025
Wastewater concentrations of rotavirus RNA are associated with infection and vaccination metrics in the USA.
Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Revealing the hidden burden: wastewater-based epidemiology for underreported and emerging infectious diseases in communities.Environmental monitoring and assessment · 2026Review
- Comparative performance of activated sludge and waste stabilization ponds for the removal of pollutants and pathogens in full-scale wastewater treatment plants in Egypt.Scientific reports · 2026Article
- Wastewater concentrations of rotavirus RNA are associated with infection and vaccination metrics in the USA.Npj viruses · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surveillance of rotavirus infections remains critical because vaccines are underutilized in the USA. Using wastewater solids measurements of rotavirus RNA collected over one year from 185 wastewater treatment plants (WWTPs) in the USA, we inferred spatiotemporal occurrence patterns of rotavirus infections and compared occurrence patterns to clinical metrics of infections and markers of vaccination coverage. We also estimated infection prevalence from wastewater measurements using available data on rotavirus RNA shedding in feces. Nationally, wastewater measurements of rotavirus RNA were correlated with clinical metrics of infection and exhibited elevated winter-spring concentrations beginning in the South. WWTP service areas characterized by markers of high vaccination coverage generally experienced a shorter duration of elevated rotavirus concentrations compared to areas characterized by markers of low vaccination coverage. Rotavirus infection prevalence estimates were highly uncertain and sensitive to shedding parameters. Wastewater monitoring of vaccine-preventable diseases is valuable for informing where vaccination campaigns should be targeted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.