Upregulation of deubiquitinase UBP16 induced by rice stripe virus infection stabilizes SHMT1 to suppress ROS accumulation and facilitate virus infection in Nicotiana benthamiana.

Kun Wang, Yaqin Wang, Shuai Fu, Yuchong Tan, Liang Wu, Yi Xu, Jianxiang Wu, Xueping Zhou

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Article in Stress biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Kun WangState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Yaqin WangState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Shuai FuState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Yuchong TanState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Liang WuState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China.

Yi XuState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China. xuyiqdpd@njau.edu.cn.

Jianxiang WuState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China. wujx@zju.edu.cn.

Xueping ZhouState Key Laboratory of Rice Biology and Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China. zzhou@zju.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China W2411024Key Technologies Research and Development Program 2022YFD1400804

6 · The paper itself

Abstract

Modification of proteins by ubiquitin is a dynamic and reversible process. It is unclear whether rice stripe virus (RSV) can modulate the plant deubiquitination pathway. In this study, we found that RSV infection can specifically upregulate the expression of the deubiquitinase NbUBP16. Further analysis revealed that NbUBP16 stabilizes serine hydroxymethyltrasferase (SHMT1) by binding to NbSHMT1 and removing its polyubiquitination modification mediated by E3 ligase MEL, which inhibits downstream SHMT1-mediated ROS accumulation and thereby facilitates RSV infection. Our findings provide new insights into the molecular arms race between pathogens and plants, demonstrating how a plant virus can undermine plant defenses by hijacking host deubiquitination pathways.

Indexed as

NbUBP16Rice stripe virusROS accumulationSHMT1Ubiquitination

Identifiers

PMID41139149

DOI10.1007/s44154-025-00265-2

PMCPMC12553715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.