Evidence map›Paper›PMID 41139102›Full record

Trial reportBehavior therapy2025

Cognitive Reappraisal as a Potential Mechanism of Unified Protocol for Emotional Disorders.

Mingcong Tang, Laura J Long, Marie Torre, Daniella Spencer-Laitt, Julián D Moreno-Villamizar, David H Barlow, Todd J Farchione

Abstract readRandomized Controlled TrialEquivalence Trial
In one paragraph

Trial report in Behavior therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mingcong TangBoston University. Electronic address: mingcong@bu.edu.
Laura J LongBoston University.
Marie TorreBoston University.
Daniella Spencer-LaittBoston University.
Julián D Moreno-VillamizarBoston University.
David H BarlowBoston University.
Todd J FarchioneBoston University.

Funding

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety DisordersR01MH090053 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BARLOW, DAVID H. · 2011 to 2015
$2.9M
NIMH NIH HHS R01 MH090053
6 · The paper itself

Abstract

This study aimed to investigate changes in cognitive reappraisal as a mechanism of the unified protocol (UP) for emotional disorders. Data were collected as part of a larger randomized clinical equivalence trial that assessed the efficacy of the UP, a transdiagnostic cognitive-behavioral therapy (CBT), relative to well-established single-disorder protocols and a wait-list control. The present sample included 132 individuals with primary diagnoses of panic disorder, generalized anxiety disorder, social anxiety disorder, or obsessive-compulsive disorder who were randomized to either the UP or the control group. They were assessed at five major time points during treatment, as well as a 6- and 12-month follow-up. Measures included the Overall Anxiety Severity and Impairment Scale for anxiety symptoms, the Overall Depression Severity and Impairment Scale for depression symptoms, and the Emotion Regulation Questionnaire to assess cognitive reappraisal. Multilevel mixed-effects models showed that cognitive reappraisal skills improved significantly over time in the UP group compared to a wait-list control group. Within the UP group, increases in cognitive reappraisal predicted subsequent reductions in anxiety and depression scores at the following time point. The greatest degree of improvement in cognitive reappraisal was observed at the last two time points during treatment, and these gains were sustained across the follow-up period. These findings underscore the importance of cognitive reappraisal, suggesting that it functions as a key transdiagnostic mechanism contributing to the UP's efficacy in treating emotional disorders. This research highlights the necessity for targeted interventions to enhance reappraisal skills, informing the optimization of the UP for individuals with emotional disorders.

Indexed as

Anxiety DisordersCognitive Behavioral TherapyEmotional RegulationPanic DisorderAdultCognitionDepressionFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPhobia, SocialTreatment OutcomeYoung Adultcognitive reappraisalemotional disordersmultilevel modelUP

Identifiers

PMID41139102
PMCPMC12553912

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.