ArticleThe Journal of pediatrics2026
Pulmonary Hemodynamics and Long-Term Outcomes in Children with Pulmonary Hypertension-Associated Bronchopulmonary Dysplasia.
Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Heterogeneity of Long-Term Cardiopulmonary Outcomes in Children Born Preterm May Benefit from Pulmonary Hypertension-Specialty Outpatient Follow-Up.Pulmonary circulation · 2026Article
- Bronchopulmonary dysplasia associated pulmonary hypertension: implications across the lifespan.Paediatric respiratory reviews · 2026Review
- Echocardiographic Detection of Pulmonary Hypertension and Right Ventricular Failure in Infants with Bronchopulmonary Dysplasia: A Survey of the BPD Collaborative.Children (Basel, Switzerland) · 2026Article
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Authors and funding
19 authors.
Funding
Abstract
objectiveTo determine whether the severity of pulmonary hypertension (PH), assessed at cardiac catheterization, is associated with bronchopulmonary dysplasia (BPD) severity and mortality. STUDY
designWe analyzed clinical data from subjects with BPD-PH enrolled in the PPHNet Registry between 2014 and 2024. BPD severity was based on the Neonatal Research Network grading system at 36 weeks postmenstrual age. Survival and clinical associations were estimated using Cox proportional hazards regression with delayed entry-to-risk-set and competing risk methodologies.
resultsThe study included 320 subjects (gestational age, 25.8 ± 2.0 weeks (range 22.2 to 31.6 weeks); postnatal age 5.0 months (IQR 3.3, 8.6; range birth to 12 years) at the time of PH diagnosis. The severity of BPD was 27% (grade 1), 44% (grade 2), and 29% grade 3. Twenty-two percent (n = 69) of subjects underwent cardiac catheterization within 1 month of echocardiographic diagnosis of PH. Hemodynamic features by cardiac catheterization were similar between grades of BPD severity. Five-year survival postdiagnosis was 94%, 94%, and 87%, respectively, for Grades 1, 2, and 3 BPD. Twenty-five of 320 (8%) subjects died, including 6 with pulmonary vein stenosis.
conclusionsAmong subjects with BPD-PH undergoing cardiac catheterization, more deaths occurred among children with Grade 3 BPD. However, there were no substantive differences in invasive measurements of pulmonary hemodynamics based on BPD severity.
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