Evidence map›Paper›PMID 41138970›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026

Proinflammatory and cytotoxic CD38

Yuko Tada, Sujit S A Suthahar, Payel Roy, Vasantika Suryawanshi, Runpei Wu, Erpei Wang, Felix S Nettersheim, Anusha Bellapu, Katarzyna Dobaczewska, Cheryl Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yuko TadaDivision of Cardiovascular Medicine, University of California, San Diego, San Diego, California, USA.
Sujit S A SuthaharLa Jolla Institute for Immunology, La Jolla, California, USA.
Payel RoyLa Jolla Institute for Immunology, La Jolla, California, USA; Immunology Center for Georgia, Augusta University, Augusta, Georgia, USA.
Vasantika SuryawanshiLa Jolla Institute for Immunology, La Jolla, California, USA.
Runpei WuLa Jolla Institute for Immunology, La Jolla, California, USA.
Erpei WangLa Jolla Institute for Immunology, La Jolla, California, USA.
Felix S NettersheimLa Jolla Institute for Immunology, La Jolla, California, USA; Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Anusha BellapuImmunology Center for Georgia, Augusta University, Augusta, Georgia, USA.
Katarzyna DobaczewskaLa Jolla Institute for Immunology, La Jolla, California, USA.
Cheryl KimLa Jolla Institute for Immunology, La Jolla, California, USA.
Florin VaidaDepartment of Family Medicine and Public Health, University of California, San Diego, San Diego, California, USA.
Gerald P MorrisDepartment of Pathology, University of California, San Diego, San Diego, California, USA.
Klaus LeyImmunology Center for Georgia, Augusta University, Augusta, Georgia, USA.
Paul J KimDivision of Cardiovascular Medicine, University of California, San Diego, San Diego, California, USA. Electronic address: pjk017@health.ucsd.edu.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
CTSA UM1 Program at University of California San Diego Altman Clinical and Translational Research InstituteUM1TR005449 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael A Hogarth, David Mitchell Smith · 2025 to 2026
$20.6M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR001442NCATS NIH HHS UM1 TR005449NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Interferon gamma (IFNG) is thought to play a central role in the pathogenesis of cardiac allograft vasculopathy (CAV) in patients with heart transplant (HTx). However, peripheral lymphocytes participating in the IFNG axis remain largely unknown in human CAV. Using peripheral blood mononuclear cells from International Society for Heart and Lung Transplant grade 2 or 3 CAV (high-grade CAV) and normal patients with HTx, we performed high-dimensional analysis (high-grade CAV, n = 6; normal HTx, n = 12) with cellular indexing of transcriptomes and epitopes using sequencing and variability, diversity, and joining segment sequencing and validated the findings using flow cytometry in an independent cohort (high-grade CAV, n = 11; normal HTx, n = 12). Among the major immune cell populations, CD8

Indexed as

CD8-Positive T-LymphocytesGraft RejectionHeart TransplantationHLA-DR AntigensImmunologic MemoryInflammationMemory T CellsADP-ribosyl Cyclase 1AdultAllograftsFemaleFollow-Up StudiesHumansInterferon-gammaMaleMembrane GlycoproteinsADP-ribosyl Cyclase 1CD38 protein, humanHLA-DR AntigensInterferon-gammaMembrane Glycoproteinscardiac allograft vasculopathyCD8(+) T cellsheart transplant

Identifiers

PMID41138970
PMCPMC12769763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.