ArticleCell2025
Adrenergic signaling coordinates distant and local responses to amputation in axolotl.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
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Who cites it
5 citing papers in PubMed.
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- The brain-limb axis: Elucidating CNS mediators of salamander limb regeneration.Current opinion in neurobiology · 2026Review
- Spinal cord regeneration deploys cell-type specific developmental and non-developmental strategies to restore neuron diversity.Nature communications · 2026Article
- Article
- The adrenal stress response involves distinct dynamics of both cortisol and corticosterone in the axolotl salamander.Lab animal · 2026Article
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Authors and funding
38 authors.
Duygu Payzin-DogruDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Tim FroitzheimDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Steven J BlairDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Siddhartha G JenaDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Hani SingerDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Julia C PaoliDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Ryan T KimDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Emil KriukovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Sarah E WilsonDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Renzhi HouDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92617, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA.
Aaron M SavageDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Victor CatDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Louis V CammarataDepartment of Statistics, Harvard University, Cambridge, MA 02138, USA.
S Y Celeste WuDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Vivien BotheMuseum für Naturkunde Berlin, Berlin, Germany.
Burcu ErdoganDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Shifa HossainDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Noah LopezDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Julia LosnerDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Juan Velazquez MatosDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Sangwon MinDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Sebastian BöhmDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Anthony E StrikerDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Kelly E DoolingDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Adam H FreedmanInformatics Group, Harvard University, 38 Oxford St., Cambridge, MA 02138, USA.
Bobby GrovesDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Benjamin TajerDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Glory KaluDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Eric WynnDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Alan Y L WongDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Nadia FröbischMuseum für Naturkunde Berlin, Berlin, Germany.
Petr BaranovSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA 02114, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Maksim V PlikusDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92617, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02138, USA.
Brian J HaasThe Broad Institute of Harvard and MIT, Cambridge, MA 02138, USA.
Isaac M ChiuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Timothy B SacktonInformatics Group, Harvard University, 38 Oxford St., Cambridge, MA 02138, USA.
Jessica L WhitedDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: jessica_whited@harvard.edu.
Funding
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MUCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2019 to 2025
$5.1MLeveraging Single-Cell Analysis to Elucidate Mechanisms of Vertebrate LimbRegenerationDP2HD087953 · NICHD · HARVARD UNIVERSITY · PI WHITED, JESSICA L. · 2015 to 2020
$3.2MRoles of body-wide injury responses in axolotl limb regenerationR01HD115272 · NICHD · HARVARD UNIVERSITY · PI JESSICA L. WHITED · 2024 to 2026
$2.5MIDENTIFYING ROADBLOCKS TO LIMB REGENERATIONR01HD095494 · NICHD · HARVARD UNIVERSITY · PI WHITED, JESSICA L. · 2019 to 2023
$1.9MInterdisciplinary Training Program in Skin BiologyT32AR080622 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen, Anand K Ganesan · 2022 to 2026
$909kBlastema-independent Mechanism for Regeneration in SalamandersR21AR078939 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GARDINER, DAVID M., PLIKUS, MAKSIM V · 2022 to 2023
$380kNIAMS NIH HHS P30 AR075047NIAMS NIH HHS R21 AR078939NIAMS NIH HHS T32 AR080622NICHD NIH HHS DP2 HD087953NICHD NIH HHS R01 HD095494NICHD NIH HHS R01 HD115272NIGMS NIH HHS T32 GM144273
Abstract
Many species regenerate lost body parts following amputation. Most limb regeneration research has focused on the immediate injury site. Meanwhile, body-wide injury responses remain largely unexplored but may be critical for regeneration. Here, we discovered a role for the sympathetic nervous system in stimulating a body-wide stem cell activation response to amputation that drives enhanced limb regeneration in axolotls. This response is mediated by adrenergic signaling, which coordinates distant cellular activation responses via the α
Indexed as
Ambystoma mexicanumRegenerationSignal TransductionAmputation, SurgicalAnimalsExtremitiesReceptors, Adrenergic, alpha-2Receptors, Adrenergic, betaStem CellsSympathetic Nervous SystemTOR Serine-Threonine KinasesReceptors, Adrenergic, alpha-2Receptors, Adrenergic, betaTOR Serine-Threonine KinasesamputationlimbmTORnoradrenalinenorepinephrineperipheral nervous systemprogenitor cellsregenerationstem cellssystemic responses
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.