Evidence map›Paper›PMID 41138493›Full record

ArticleUltrasonics sonochemistry2025

Rapidly dissolving polymeric microbubbles promote supersaturation and in-situ formation of acoustic nanobubbles capable of dynamic pressure sensing.

Quang Tran, Garam Lee, Michelle Balcarcel-Monzon, Yongzhi Zhang, Saffron Dominguez, Kristen Sack, John N Kheir, James Bird, Nathan McDannold, Yifeng Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Quang TranDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School. Boston, MA 02115, USA.
Garam LeeDepartment of Mechanical Engineering, Boston University, Boston, MA 02215, USA.
Michelle Balcarcel-MonzonDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA.
Yongzhi ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School. Boston, MA 02115, USA.
Saffron DominguezDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA.
Kristen SackDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA.
John N KheirDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA. Electronic address: John.Kheir@childrens.harvard.edu.
James BirdDepartment of Mechanical Engineering, Boston University, Boston, MA 02215, USA. Electronic address: jbird@bu.edu.
Nathan McDannoldDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School. Boston, MA 02115, USA. Electronic address: njm@bwh.harvard.edu.
Yifeng PengDepartment of Cardiology, Department of Pediatrics. Boston Children's Hospital, Harvard Medical School. Boston, MA 02115, USA. Electronic address: yifeng.peng@childrens.harvard.edu.

Funding

Intravenous oxygen for the treatment of cardiac arrestR01HL178815 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Yifeng Peng · 2025 to 2026
$1.7M
NHLBI NIH HHS R01 HL178815
6 · The paper itself

Abstract

Developing noninvasive methods for monitoring intravascular and intracardiac pressures is crucial for advancing the diagnosis and management of cardiovascular diseases. Here we report an approach utilizing pH-responsive polymeric microbubbles (PMBs) as precursors to produce in situ generated nanobubbles (NBs) as acoustic pressure sensors. Upon exposure to physiologic pH, PMBs rapidly dissolve their gas core, inducing gas supersaturation and transient formation of acoustically active NBs with cavitation thresholds characteristic of their sizes. In situ generated NBs exhibit subharmonic emission inversely correlated with hydrostatic pressure. As proof of concept, we show in an ex vivo Langendorff working heart model in situ generated NBs achieve excellent linear sensitivity to monitor intracardiac pressures (R

Indexed as

AcousticsMicrobubblesPolymersPressureAnimalsHydrogen-Ion ConcentrationSolubilityPolymersCavitationGas deliveryMicrobubblesNanobubblesPressure sensingSupersaturationUltrasound

Identifiers

PMID41138493
PMCPMC12590548

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.