Evidence map›Paper›PMID 41138491›Full record

ArticleUltrasonics sonochemistry2025

Biodegradable Mn-LDH-Ce6 potentiates cGas-STING pathway activation through sonodynamic-propelled pyroptosis for synergistic tumor immunotherapy.

Jiaying Chang, Guoqing Zhu, Guanglei Lv, Chunxia Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. CaMaterials today. Bio · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiaying ChangCentral Laboratory, Zhoupu Hospital, Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, PR China; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, PR China.
Guoqing ZhuInstitute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, PR China.
Guanglei LvCentral Laboratory, Zhoupu Hospital, Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, PR China. Electronic address: lvguanglei@fudan.edu.cn.
Chunxia LiInstitute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, PR China. Electronic address: cxli@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While immunotherapy represents a breakthrough in cancer treatment by enabling specific tumor targeting with reduced toxicity, its success is often impeded by the immunosuppressive tumor microenvironment (TME). Conditions within the TME, particularly hypoxia and high glutathione (GSH) concentrations, actively suppress immune activation, leading to suboptimal therapeutic outcomes. To address these limitations, we developed a manganese-doped layered double hydroxide nanosystem loaded with chlorin e6 (Mn-LDH-Ce6). By catalyzing the decomposition of endogenous H

Indexed as

HydroxidesImmunotherapyManganeseMembrane ProteinsNeoplasmsPorphyrinsPyroptosisSignal TransductionUltrasonic WavesAnimalsCell Line, TumorChlorophyllidesHumansMiceReactive Oxygen SpeciesTumor MicroenvironmentChlorophyllidesHydroxidesManganeseMembrane ProteinsphytochlorinPorphyrinsReactive Oxygen SpeciescGAS-STING pathwayLayered double hydroxidePyroptosisSonodynamic therapyTumor immunotherapy

Identifiers

PMID41138491
PMCPMC12594942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.