ArticleBrazilian journal of otorhinolaryngology
Causal role of immune cells in allergic rhinitis: A bidirectional Mendelian randomization study.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePrevious observational studies have indicated an association between various immune cells and allergic rhinitis; however, the causal relationship remains uncertain. This study seeks to further investigate the causal link between immune cells and allergic rhinitis through bidirectional two-sample Mendelian randomization analysis.
methodsAllergic rhinitis related data were obtained from the MRC-IEU database, while data for 731 immune cells were sourced from the GWAS catalog. The causal association between immune cells and allergic rhinitis was assessed using inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode methods. Stability and reliability of the findings were evaluated through Cochran's Q test, MR-Egger intercept p-value, and leave-one-out analysis.
resultsPrimarily based on IVW methods, 38 distinct immunocyte phenotypes were identified as potentially influencing allergic rhinitis (p < 0.05), while allergic rhinitis was found to potentially impact 20 different immunocyte phenotypes (p < 0.05). The results for heterogeneity, horizontal pleiotropy, and sensitivity analyses demonstrated stability.
conclusionThis study establishes a strong genetic correlation between immune cells and allergic rhinitis, enhances current knowledge regarding the role of immune cells in AR, and offers potential targets for the development of novel immune-based therapeutic strategies. LEVEL OF EVIDENCE: Level 5.
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