Evidence map›Paper›PMID 41138219›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2025

Liver androgen receptor knockout attenuates high-fructose diet-induced glucose dysregulation in female mice.

Trinitee Oliver, Adjoa Osei-Ntansah, Claire Falzarano, Md Ahasanur Rahman, Taylor Lofton, Guyton Harvey, Stanley Andrisse

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Trinitee OliverDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.ORCID 0000-0002-2247-8940
Adjoa Osei-NtansahDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.
Claire FalzaranoDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.
Md Ahasanur RahmanDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.ORCID 0000-0002-3003-459X
Taylor LoftonDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.
Guyton HarveyDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.
Stanley AndrisseDepartment of Physiology and Biophysics, Howard University, College of Medicine, Washington, District of Columbia, United States.ORCID 0000-0003-1484-9155

Funding

Bridges to the Baccalaureate Research Training Program at Howard University and Baltimore City Community CollegeT34GM142610 · NIGMS · HOWARD UNIVERSITY · PI Stanley Andrisse, Anil Malaki · 2022 to 2026
$1.4M
The cellular molecular regulation of differing mechanisms of insulin resistance.R01DK126892 · NIDDK · HOWARD UNIVERSITY · PI ANDRISSE, STANLEY · 2022 to 2025
$1.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T34GM142610-03HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) 5R01DK126892-03National Science Foundation (NSF) EES 1931045NICHD NIH HHS L50 HD089300NIDDK NIH HHS R01 DK126892NIGMS NIH HHS T34 GM142610
6 · The paper itself

Abstract

The Western diet, rich in fats and sugars such as fructose, contributes significantly to the global rise in obesity and type 2 diabetes mellitus. Although both high-fat diets (HFD) and high-fructose diets (HFrD) are known to impair hepatic insulin signaling, the specific mechanisms and potential sex-specific differences remain underexplored. Moreover, the role of hepatic androgen receptor (AR) in modulating these effects, particularly in females, has not been fully elucidated. Here, we investigated the contribution of hepatic AR to HFrD-induced metabolic dysfunction using liver-specific AR knockout (LivARKO) mice of both sexes. Male and female LivARKO and wild-type (WT) littermates were subjected to either a HFrD or calorie-matched control diet from 4 to 12 wk of age and underwent several metabolic tests during

Indexed as

FructoseGlucose IntoleranceLiverReceptors, AndrogenAnimalsBlood GlucoseDiet, High-FatFemaleGlucose Tolerance TestInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutSex CharacteristicsAR protein, mouseBlood GlucoseFructoseReceptors, Androgenandrogen receptorglucose metabolismhigh-fructose dietinsulin resistanceliver metabolism

Identifiers

PMID41138219
PMCPMC12756818

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.