Evidence map›Paper›PMID 41138206›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes.

Salaheldeen Elsaid, Xiangdong Wu, Junkai Hu, Nigus Ambye, Sui Seng Tee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Salaheldeen ElsaidRadiology Department, University of Maryland, Baltimore, Maryland, United States.ORCID 0000-0002-8362-9378
Xiangdong WuRadiology Department, University of Maryland, Baltimore, Maryland, United States.ORCID 0009-0004-8739-9540
Junkai HuRadiology Department, University of Maryland, Baltimore, Maryland, United States.
Nigus AmbyeRadiology Department, University of Maryland, Baltimore, Maryland, United States.
Sui Seng TeeRadiology Department, University of Maryland, Baltimore, Maryland, United States.ORCID 0000-0002-9891-4622

Funding

Longitudinal Metabolic Imaging of the Brain in SynucleinopathyR21AG084142 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SON, JUNSEOK, TEE, SUI SENG · 2023 to 2025
$1.3M
Fructose Metabolism as a Biomarker for Monitoring Hepatocellular CarcinomaR21CA245492 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI TEE, SUI SENG · 2020 to 2020
$397k
HHS | National Institutes of Health (NIH) R21AG084142HHS | National Institutes of Health (NIH) R21CA245492NCI NIH HHS R21 CA245492NIA NIH HHS R21 AG084142
6 · The paper itself

Abstract

Excessive intake of fructose and fats disrupts hepatocyte function by overwhelming endoplasmic reticulum (ER) capacity, leading to unresolved protein stress and progression to metabolic dysfunction-associated steatohepatitis (Shepherd EL, Saborano R, Northall E, Matsuda K, Ogino H, Yashiro H, Pickens J, Feaver RE, Cole BK, Hoang SA, Lawson MJ, Olson M, Figler RA, Reardon JE, Nishigaki N, Wamhoff BR, Günther UL, Hirschfield G, Erion DM, Lalor PF.

Indexed as

Endoplasmic ReticulumEndoplasmic Reticulum StressFructokinasesHepatocytesProteostasisAnimalsEndoribonucleasesFructoseHumansMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseProtein Serine-Threonine KinasesTranscription Factor CHOPUnfolded Protein ResponseEndoribonucleasesErn1 protein, mouseFructokinasesFructoseketohexokinaseProtein Serine-Threonine KinasesTranscription Factor CHOPX-Box Binding Protein 1apoptosisER stressketohexokinaseMASHunfolded protein response (UPR)

Identifiers

PMID41138206
PMCPMC12765227

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.