Evidence map›Paper›PMID 41138058›Full record

ArticleGeroScience2026

Novel evidence of age-related cortical and subcortical constraints in cross-education.

Ummatul Siddique, Ashlyn K Frazer, Jamie Tallent, Oliver Hayman, Justin Andrushko, Matt S Stock, Joshua Carr, Yonas Akalu, Mohamad Rostami, Sergio Uribe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ummatul SiddiqueMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Ashlyn K FrazerMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Jamie TallentMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Oliver HaymanMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Justin AndrushkoDepartment of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-Upon-Tyne, UK.
Matt S StockSchool of Kinesiology and Rehabilitation Sciences, University of Central Florida, Orlando, FL, USA.
Joshua CarrDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Yonas AkaluMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Mohamad RostamiMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia.
Sergio UribeDepartment of Medical Imaging and Radiation Sciences, School of Primary and Allied Care, Monash University, Clayton, Australia.
Simon WalkerNeuroMuscular Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Dawson J KidgellMonash Exercise Neuroplasticity Research Unit, School of Primary and Allied Care, Monash University, Frankston, Australia. dawson.kidgell@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-education (CE), the phenomenon whereby unilateral strength training induces neuromuscular adaptations in the contralateral limb, is underpinned by distributed cortical and subcortical plasticity. This study evaluated acute neural responses to a single bout of metronome-paced unilateral strength training in younger (n = 17; 27 ± 6 years) and older adults (n = 18; 67 ± 5 years). Neurophysiological assessments included corticospinal excitability and inhibition via transcranial magnetic stimulation (TMS), intracortical inhibition through short-interval intracortical inhibition (SICI), and reticulospinal drive using the StartReact paradigm. Following training, younger adults exhibited a significant reduction in the responsiveness of intracortical inhibitory interneurons, reflected as a release of SICI (pre: 58.05, 95% CI 48.83-67.27; post: 68.88, 95% CI 59.69-78.06; p < 0.01), consistent with diminished GABA-

Indexed as

AgingMotor CortexMuscle, SkeletalNeuronal PlasticityResistance TrainingAdaptation, PhysiologicalAdultAgedAge FactorsElectromyographyEvoked Potentials, MotorFemaleHumansMaleNeural InhibitionPyramidal TractsAgingCorticospinal excitabilityCross-educationIntracortical inhibitionNeuroplasticityStartReactStrength training

Identifiers

PMID41138058
PMCPMC13574755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.