Evidence map›Paper›PMID 41138045›Full record

ArticleInternational ophthalmology2025

Efficacy of selective laser trabeculoplasty for elevated intraocular pressure in eyes with prior laser peripheral iridotomy.

Lorenzo Bosque, Rohit Reddy, Sagar Shah, Wesam Shamseldin Shalaby, Dilru Amarasekera, Lauren E Hock, Natasha Nayak Kolomeyer, Reza Razeghinejad, Joel S Schuman, Jonathan Myers and 1 more

Abstract read
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In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Gasotransmitters in Glaucoma: A New Paradigm.Bulletin of pharmaceutical research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lorenzo BosqueGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Rohit ReddyGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Sagar ShahGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Wesam Shamseldin ShalabyGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Dilru AmarasekeraGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Lauren E HockGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Natasha Nayak KolomeyerGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Reza RazeghinejadGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Joel S SchumanGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Jonathan MyersGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA.
Ping HuangGlaucoma Department, Wills Eye Hospital, Philadelphia, PA, USA. phuang@willseye.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the long-term efficacy and safety of selective laser trabeculoplasty (SLT) in patients who have previously undergone laser peripheral iridotomy (LPI).

designSingle-center, retrospective cohort study. PATIENTS AND

methodsEyes with a history of LPI that subsequently underwent SLT at Wills Eye Hospital between 2013 and 2022, with at least one year of follow-up, were enrolled as the study group. The control group consisted of individuals diagnosed with primary open-angle glaucoma (POAG) who underwent SLT treatment during the same time period and had no history of LPI. Baseline characteristics and post-SLT data during the 1-year follow-up period were compared between groups. Primary success was defined as IOP reduction ≥ 20% without the addition of glaucoma medications. Secondary success was defined as IOP reduction < 20% but with a reduction in the number of glaucoma medications. Success was evaluated at 6 and 12 months.

results73 eyes from 53 patients were included in the study group, along with 83 eyes from 79 patients in the control group. The study group had a similar primary success rate compared with the control group at 6 months (45.2 vs. 33.7%, P = 0.188), while significantly higher at 12 months (47.9 vs. 31.3%, P = 0.048). Secondary success was comparable in both groups at 6 and 12 months. Higher baseline IOP (P = 0.048) and narrower angle of approach (P = 0.005) were significantly associated with higher success. No complications, such as IOP spike exceeding 10 mmHg or prolonged inflammation, were observed in either group.

conclusionsSLT effectively and safely lowered the IOP in patients who have had previous LPI for narrow angle. SLT may be considered as a potential treatment option for selected patients with prior LPI and persistently elevated IOP.

Indexed as

Glaucoma, Open-AngleIntraocular PressureIridectomyIrisLaser TherapyTrabeculectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTonometry, OcularTrabecular MeshworkTreatment OutcomePeripheral laser iridotomyPrimary angle-closure glaucomaSelective laser trabeculoplasty

Identifiers

PMID41138045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.