ArticleJournal of nephrology2025
Evaluating the impact of change of the reference value of serum creatinine in the diagnosis, staging and outcome of acute kidney injury in critically ill children: an exploratory study.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundThe current definition of acute kidney injury (AKI) using Kidney Disease Improving Global Outcomes (KDIGO) does not account for within-subject biological variation or reference change value (RCV) of serum creatinine (sCr),which may affect its reliability. The aim of this study was to derive and estimate the reference change value of sCr in children and evaluate the impact of using the reference change value-optimized creatinine criteria (KDIGO
methodsThe reference change value of sCr based on age and initial sCr was derived from data regarding 420 children without risk factors for AKI (derivation cohort). In a cohort of 394 children admitted to the pediatric intensive care unit (PICU) (test cohort), AKI staging was done by KDIGO and KDIGO
resultsIn the derivation cohort (n = 420), our analysis revealed that the younger the age and the lower the sCr, the higher the variability of sCr, with the highest reference change value in the 1 month to 1 year age group (12.1%;median sCr 0.36 mg/dL). In the test cohort (n = 394), the burden of AKI was lower by 15.7% with KDIGO
conclusionReference change value was highest in younger children with lower sCr. While AKI classified by KDIGO
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