ArticleInternational ophthalmology2025
Association of inflammatory susceptibility genes with myopia in Chinese children.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Polymorphisms of 4 Common Genes and High Myopia Risk: A Comprehensive Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Pooled it
- The application of artificial intelligence in myopia prediction for children and adolescents: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Myo-inflam: a mini review on inflammatory pathways driving scleral remodeling and axial elongation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeTo investigate the association between single nucleotide polymorphisms (SNPs) in inflammation-related genes and high myopia in Chinese children, as well as to explore potential risk and protective genetic markers for early identification.
methodsA total of 458 students aged 10-13 years from Taibo School, Jiangxi Province, China, were enrolled in this study. Participants with high myopia (spherical equivalent [SE] ≤ - 6.0 D) or emmetropia (- 0.5 D < SE < + 1.0 D) were genotyped for 47 targeted SNPs using the MassARRAY platform. Logistic regression models, adjusting for age and sex, were used to evaluate SNP associations with high myopia. Linkage disequilibrium and haplotype analyses were performed.
resultsCompared with emmetropia, SNPs rs2857656, rs3760396 (CCL2), rs2317130 (TGFβ1), rs2071230 (MMP1), rs315952 (IL1RN), and rs1143627 (IL1β) were significantly associated with high myopia. Haplotype analysis identified risk (C-C-T) and protective (G-T, G-T-C) haplotypes in CCL2 and TGFβ1.
conclusionThese findings suggest that inflammatory gene polymorphisms may contribute to the development of high myopia in children.
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Registered trials
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