Evidence map›Paper›PMID 41138017›Full record

ReviewCancer metastasis reviews2025

Lymphatic metastasis in pancreatic cancer: from bedside to bench and back.

Haoyu Shi, Cheng Qin, Yutong Zhao, Bangbo Zhao, Zeru Li, Tianyu Li, Lirui Huang, Weibin Wang

Abstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haoyu Shi *Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Cheng Qin *Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Yutong Zhao *Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Bangbo ZhaoDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Zeru LiDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Tianyu LiDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Lirui HuangDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China.
Weibin WangDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100023, People's Republic of China. wwb_xh@163.com.

Funding

Beijing Natural Science Foundation 7232127Capital's Funds for Health Improvement and Research 2024-2-4017National Natural Science Foundation of China 82173074
6 · The paper itself

Abstract

Pancreatic cancer is an extremely aggressive and lethal malignant cancer; almost half of the patients have distant metastasis when first diagnosed, and many challenges arise during treatment. Lymph node metastasis is a vital indicator of disease progression in pancreatic cancer and directly influences patient prognosis and survival rate. The cancer cells invade the lymphatics, promote the growth of lymphatics, propagate to lymph nodes, and finally settle down in lymph nodes. Aiming at this process, treatment modalities involving surgery, targeted therapy, and nanodelivery of chemotherapy are tested regarding their efficacy in both local tumor management and lymph node metastasis. As lymph node metastasis presents a poor prognosis and higher recurrence rate, precise assessment of lymph node metastasis is imperative for clinical management in pancreatic ductal adenocarcinoma. Precise evaluation of lymph node metastasis will not only help in formulating personalized treatment but also provide more accurate prognostic information to the patients. This review aims at synthesizing current knowledge of the molecular mechanisms, treatment options, clinical implications, and evaluation techniques regarding lymph node metastasis in pancreatic cancer, hence allowing a focused perspective for clinicians and researchers in striving for more effective management strategies against lymph node metastasis of pancreatic cancer.

Indexed as

Pancreatic NeoplasmsAnimalsHumansLymphatic MetastasisPrognosisLymphatic metastasisLymph nodesPancreatic cancer

Identifiers

PMID41138017
PMCPMC12553592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.