ArticlePharmacology research & perspectives2025
Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic, GC-MS Profiling, and Molecular Docking Studies.
Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation ofAnalytical science advances · 2026Article
- Phytochemical Characterization and Neuropharmacological Assessment ofFood science & nutrition · 2026Article
- Emphasizing the Pharmacological Potentials of the Methanolic Extract ofVeterinary medicine international · 2026Article
- Pharmacological and Computational Insights Into the Analgesic, Antipyretic, and Antidiarrheal Potential ofTheScientificWorldJournal · 2026Article
- Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic, GC-MS Profiling, and Molecular Docking Studies.Pharmacology research & perspectives · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
Jatropha gossypifolia L., a member of the Euphorbiaceae family, has been traditionally used in the treatment of various ailments. However, its neuropharmacological, cytotoxic, and anthelmintic potentials have not been thoroughly investigated. The methanolic fruit extract of J. gossypifolia (JGF-ME) was evaluated for anxiolytic activity using the Elevated Plus Maze (EPM), Hole Board Test (HBT), and Light-Dark Box Test (LDT); antidepressant activity using the Forced Swimming Test (FST) and Tail Suspension Test (TST); and sedative effects through the Open Field and Hole Cross tests. Cytotoxicity was assessed via the Brine Shrimp Lethality Assay (BSLA), and anthelmintic activity was evaluated against Pheretima posthuma. GC-MS was used for phytochemical screening, followed by molecular docking and ADME/T analyses of the identified compounds. JGF-ME exhibited a significant, dose-dependent anxiolytic effect in EPM, HBT, and LDT. At 400 mg/kg, it significantly reduced immobility in FST and TST (p < 0.001), indicating significant antidepressant activity. The extract also exhibited notable sedative effects, as evidenced by reduced locomotor activity in the Open Field and Hole Cross tests at doses of 200 and 400 mg/kg. In BSLA, JGF-ME displayed moderate cytotoxicity (LC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.