ReviewClinical and experimental medicine2025
The role of skin barrier and immune abnormalities in the pathogenesis of Rosacea.
Review in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Neurogenic Rosacea and Facial Dysesthesia: Neurovascular-Immune Mechanisms and Translational Therapeutic Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- Sulforaphane in Cutaneous Disorders and Skin Injury: Mechanisms, Evidence, and Clinical Perspectives.Nutrients · 2026Review
- Formulation and Biological Evaluation ofAntioxidants (Basel, Switzerland) · 2026Article
- Causal Effects of Diet on Atopic Dermatitis: A Mendelian Randomization Study Implicating Lipid Pathways and Clinical Implications.Clinical, cosmetic and investigational dermatology · 2026Article
- Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis.Drug design, development and therapy · 2026Review
- Beyond Lifting: Superficial-Targeted Monopolar Radiofrequency for Erythematotelangiectatic Rosacea.Clinical, cosmetic and investigational dermatology · 2026Article
- Neuro-immune-vascular interactions in rosacea and hypertension: a mechanistic review.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosacea is marked by a compromised skin barrier, abnormal immune responses, and vascular dysregulation. It typically manifests as persistent or intermittent flushing, along with papules and pustules. These symptoms are often accompanied by burning, itching, or stinging sensations that can significantly affect the physical and mental well-being of those affected. Multiple factors contribute to the increased sensitivity in rosacea-affected skin, including barrier dysfunction and inflammatory activation. While the pathogenesis of rosacea is not fully understood, compromised skin barriers and aberrant immune responses are recognized as key contributors. This review aims to summarize recent findings on rosacea and its underlying pathological mechanisms while exploring the interplay between abnormalities in the skin barrier and immune response. Consequently, we propose that targeting both the skin barrier and immune response may represent a novel therapeutic strategy for modulating the inflammatory pathways associated with rosacea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.