ArticleLasers in medical science2025
Effect of vaginal laser therapy for gynecologic patients on vaginal microbiota: a prospective cohort study.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical and vaginal microbiota effects of oral Lactobacillus crispatus M247 combined with vaginal laser therapy in menopausal women with atrophic vulvovaginitis: a prospective, randomized and controlled study.Lasers in medical science · 2026Trial
- Fractional COInternational urogynecology journal · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
purposeWe aimed to evaluate vaginal microbiota distribution before and after laser therapy for gynecologic patients with stress urinary incontinence (SUI) and genitourinary syndrome of menopause (GSM).
methodsFifty patients undergoing CO₂ vaginal laser treatment were enrolled. The primary outcomes included UDI-6, IIQ-7, OABSS, and VSQ-21 scores before and at 1, 2, and 3 months after laser treatment, as well as vaginal microbiota diversity before and 1 month after laser treatment.
resultsUDI-6, IIQ-7, OABSS, and VSQ-21 scores for patients who received CO₂ laser therapy all showed significant improvement at 1, 2, and 3 months post-treatment. Vaginal pH showed no significant change after laser treatment. Overall, 91 samples were successfully sequenced. Alpha diversity showed significant differences in the menopause (p = 0.034) and GSM (p = 0.004) groups, but not between pre- and post-laser treatment samples. PERMANOVA revealed differences in microbiota composition associated with menopause (p = 0.009) and SUI (p = 0.026). Beta diversity analysis showed no significant treatment effect due to high inter-individual variability. The six most abundant vaginal bacterial genera included Lactobacillus (40.4%), Gardnerella (8.4%), Prevotella (7.4%), Escherichia-Shigella (6.0%), Streptococcus (5.6%), and Bifidobacterium (3.2%), with changes in Lactobacillus dominance observed in some patients post-treatment. Network analysis revealed that Gardnerella disappeared post-laser treatment, as Lactobacillus increased in abundance.
conclusionCO₂ laser treatment may improve SUI and GSM, and be associated with shifts in microbiota.
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