Evidence map›Paper›PMID 41137892›Full record

ReviewNeuroscience bulletin2026

Genetically Modified Primate Models for Brain Disorder Research.

Yi Yang, Jianbang Lin, Mengqi Li, Lixin Yang, Zhonghua Lu, Ting Yan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi Yang *Research Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Jianbang Lin *Research Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Mengqi LiResearch Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Lixin YangResearch Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Zhonghua LuResearch Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. zh.lu@siat.ac.cn.
Ting YanResearch Center for Primate Neuromodulation and Neuroimaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. ting.yan@siat.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain disorders have imposed an escalating socioeconomic burden in recent years, yet critical gaps persist in understanding their pathogenesis and developing effective therapies. Nonhuman primate (NHP) models provide invaluable insights into human brain disorders due to their unique neuroanatomical and neurophysiological similarities with humans. Here, we review the current landscape of genetically modified NHP-based research in brain disorders, emphasizing the pivotal role of gene editing in disease modeling and the distinct advantages of transgenic NHP models in deciphering disease mechanisms. While key mechanistic questions and technical hurdles remain, NHP models hold immense promise in overcoming challenges and accelerating the development of therapeutics for brain disorders.

Indexed as

Animals, Genetically ModifiedBrain DiseasesDisease Models, AnimalPrimatesAnimalsGene EditingHumansAnimal modelsBrain disordersGene editingNonhuman primates

Identifiers

PMID41137892
PMCPMC12950133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.