Evidence map›Paper›PMID 41137822›Full record

ReviewThe Journal of investigative dermatology2026

The Polygenic Architecture of Human Diseases Affecting the Hair Follicle.

Anna L Brinks, Carli D Needle, Olivia D Perez, Jerry Shapiro, Kristen I Lo Sicco, Michael A Occidental, Aristotelis Tsirigos, Lynn Petukhova

Abstract readReview
In one paragraph

Review in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A Comprehensive Review of GWASs of Human Hair Traits.The Journal of investigative dermatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna L BrinksThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Carli D NeedleThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Olivia D PerezThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Jerry ShapiroThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Kristen I Lo SiccoThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Michael A OccidentalThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA.
Aristotelis TsirigosDivision of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA; Applied Bioinformatics Laboratories, Office of Science and Research, New York University Grossman School of Medicine, New York, New York, USA.
Lynn PetukhovaThe Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, New York, USA; Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA. Electronic address: Lynn.Petukhova@nyulangone.org.

Funding

Establishing the contributions of monogenic etiologies to hidradenitis suppurativapathogenesisR01AR080796 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Lynn Petukhova · 2023 to 2026
$2.1M
Identification of biologically relevant subtypes of hidradenitis suppurativaK01AR075111 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PETUKHOVA, LYNN · 2020 to 2024
$534k
NIAMS NIH HHS K01 AR075111NIAMS NIH HHS R01 AR080796
6 · The paper itself

Abstract

Disorders affecting the hair follicle (HF) and pilosebaceous unit impose psychosocial and financial burdens on patients and may signal risk for other medical conditions. Human genetic studies help to identify key physiological mechanisms that govern health and are increasingly used to improve drug development. GWASs identify genetic variants that are common in the population and implicate disease mechanisms that are widely shared among patients. In this study, we synthesize knowledge about the biology of the pilosebaceous unit that has been derived from GWASs of hair-related diseases. We identify the key genetic drivers and reveal fundamental biological themes that cut across diseases to identify crucial regulators of HF health.

Indexed as

Hair DiseasesHair FollicleMultifactorial InheritanceGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansAcneAlopeciaGWASsHair follicleHidradenitis suppurativa

Identifiers

PMID41137822
PMCPMC13373509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.