ArticlePharmacoepidemiology and drug safety2025
Association Between Statins Use and Major Bleeding in Patients Using Direct Oral Anticoagulants for Atrial Fibrillation.
Article in Pharmacoepidemiology and drug safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Validation of an AI-Assisted Framework for Systematic Bias Assessment in Observational Studies.Journal of evaluation in clinical practice · 2026Article
- Association Between Statins Use and Major Bleeding in Patients Using Direct Oral Anticoagulants for Atrial Fibrillation.Pharmacoepidemiology and drug safety · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundDirect oral anticoagulants (DOAC) were developed as an alternative to vitamin K antagonists in the treatment of NVAF. Statins are frequently prescribed drugs for the prevention of atherosclerotic cardiovascular disease. A potential interaction between DOACs and statins has been described, suggesting that their concomitant use may increase the risk of major bleeding (MB). PURPOSE: To estimate the risk of MB associated with concomitant use of DOACs and statins to assess potential safety issues.
methodsA case-control study nested in a cohort of new users of DOACs was performed in BIFAP. Cases were defined as MB events and matched to four controls by risk-set sampling. Treatment episodes were built to define the participants' exposure according to their use at index date as current, recent, past, or no use. Exposure was also assessed in relation to its continuity and duration. Variables were created based on the concomitant use of DOACs and statins to study the interaction, using conditional logistic regression to estimate the risk of MB.
resultsaOR (95% CI) for current use of DOAC or statin use were 1.35 (0.96-1.9) and 0.72 (0.59-0.88). aOR for their concomitant use was 1.31 (0.83-2.07) compared to nonuse of either of them. DOAC continuous use (1.27; 0.8-2.03) and long-term (1.11; 0.67-1.81) treatment was associated with smaller risks than noncontinuous (1.40; 0.85-2.32) and short-term treatment (1.43; 0.94-2.45). Analyses by individual DOACs and statins showed similar results except for edoxaban, which had low numbers.
conclusionsThere was no evidence to suggest an interaction between DOACs and statins and the risk of MB. Regular use of DOACs is important to minimize their impact on MB onset.
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