Evidence map›Paper›PMID 41137713›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

The Knockdown of ACTL6A Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma by Modulating the Wnt/β-Catenin Signaling Pathway.

Shuo Zhou, Tongyou Sun, Likun Liu, Dong Guo, Xueyuan Zhang, Wenbin Shen, Shaolin Gao, Shuchai Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuo ZhouDepartment of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0004-8644-3431
Tongyou SunDepartment of Radiation Oncology, Chengde Central Hospital, Chengde, Hebei, China.
Likun LiuDepartment of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Dong GuoDepartment of Radiation Oncology, Weifang People's Hospital, Weifang, Shandong, China.
Xueyuan ZhangDepartment of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Wenbin ShenDepartment of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shaolin GaoDepartment of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shuchai ZhuDepartment of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Funding

Chengde Municipal Science and Technology Bureau 202404B078Hebei Province Science and Technology Support Program H2024206457Natural Science Foundation H2022206459
6 · The paper itself

Abstract

Actin-like protein 6A (ACTL6A) is thought to be associated with the survival and prognosis of patients with a variety of human cancers. This study investigates the effect of ACTL6A knockdown on ESCC radiosensitivity and explores molecular mechanisms that may enhance radiotherapy efficacy. The ACTL6A expression level was increased in esophageal squamous carcinoma cells after radiation irradiation. The protein expression level of ACTL6A in tumor tissue samples of clinical esophageal squamous cell carcinoma patients was analyzed by immunohistochemistry, and it was found that the prognosis of the high expression group was worse than that of the low expression group. Further knocking down the ACTL6A gene in esophageal squamous cell carcinoma cells, it was found that ACTL6A could regulate the proliferation, migration, invasion, DNA damage repair, cell cycle, and apoptosis of esophageal squamous cell carcinoma cells, which further affected the radiosensitivity of esophageal squamous cell carcinoma cells. Through functional enrichment analysis of gene set enrichment and validation of the mechanism using the Wnt pathway inhibitor XAV939, it was shown that ACTL6A is involved in the regulation of the Wnt/β-catenin signaling pathway. Knockdown of ACTL6A can inhibit the activity of this pathway, thereby increasing the radiosensitivity of esophageal squamous cell carcinoma. ACTL6A may become an important therapeutic target for esophageal squamous cell carcinoma, providing a necessary theoretical basis for future treatment strategies.

Indexed as

ActinsEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaRadiation ToleranceWnt Signaling PathwayApoptosisbeta CateninCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMaleMiddle AgedActinsbeta CateninACTL6Aepithelial‐mesenchymal transitionesophageal squamous cell carcinomaradiosensitivityWnt/β‐catenin signaling pathway

Identifiers

PMID41137713
PMCPMC12553302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.