Evidence map›Paper›PMID 41137661›Full record

ReviewInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

A comprehensive review of aneurysm clip materials and artifact reduction techniques.

Trey Seymour, Seyed Behnam Jazayeri, Sherief Ghozy, Lorenzo Rinaldo, Ramanathan Kadirvel

Expression of concernAbstract readReview
In one paragraph

Review in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Trey SeymourUniversity of Colorado Anschutz, Denver, CO, USA.ORCID 0000-0002-1824-077X
Seyed Behnam JazayeriPulmonary, Allergy, and Critical Care Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-2860-6496
Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5629-3023
Lorenzo RinaldoDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Ramanathan KadirvelDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6786-9953

Funding

Computational and Biological Approach to Flow DiversionR01NS076491 · NINDS · MAYO CLINIC ROCHESTER · PI Juan R Cebral, DAVID F KALLMES · 2011 to 2026
$7.4M
Drug Eluting Embolization Coils for Improved Treatment of Intracranial AneurysmsR44NS107111 · NINDS · ANCURE, LLC · PI BETTINGER, CHRISTOPHER JOHN, KADIRVEL, RAMANATHAN · 2018 to 2020
$1.2M
Enhanced endothelialization of nanomatrix coated flow diverter for intracranial aneurysmsR43NS110114 · NINDS · ENDOMIMETICS, LLC · PI HWANG, PATRICK, KADIRVEL, RAMANATHAN · 2019 to 2019
$563k
Rapidly healing flow diverters using magnetic cell targeting for intracranial aneurysm treatmentR21NS128199 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI KADIRVEL, RAMANATHAN, TEFFT, BRANDON J · 2022 to 2023
$447k
NINDS NIH HHS R01 NS076491NINDS NIH HHS R21 NS128199NINDS NIH HHS R43 NS110114NINDS NIH HHS R44 NS107111
6 · The paper itself

Abstract

High-resolution imaging is critical for the diagnosis, treatment planning, and postoperative monitoring of cerebral aneurysms, which affect up to 5% of the population and pose a significant risk of rupture and subarachnoid hemorrhage. Surgical clipping remains a definitive treatment option, but metallic clips can introduce substantial imaging artifacts, complicating posttreatment assessment. This review synthesizes current knowledge on the impact of aneurysm clip materials and designs on artifact generation and explores strategies for artifact mitigation. Conventional materials like titanium are favored for their biocompatibility and reduced ferromagnetism but still cause beam hardening, streak artifacts, and signal loss in CT and MRI scans. Emerging alternatives, including ceramics, composites, polymers, and bioresorbable clips, show promise in reducing artifacts while maintaining mechanical reliability. Innovations in clip design, such as fenestrated or low-profile models, further aid in minimizing imaging distortion. Advanced imaging methods, including dual-energy CT, iterative reconstruction algorithms, and metal artifact reduction software, demonstrate significant improvements in image quality but may introduce limitations such as increased processing demands or subtle anatomical distortions. Future directions emphasize the development of next-generation clip materials, robotic-assisted surgical approaches, and artificial intelligence-driven reconstruction techniques to further optimize visualization and patient safety. Continued research and multidisciplinary collaboration will be essential to translate these innovations into routine neurosurgical practice.

Indexed as

advanced imaging techniquesCerebral aneurysmclip materialsimaging artifactsmetal artifact reductionmicrosurgical clipping

Identifiers

PMID41137661
PMCPMC12553550

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.