Evidence map›Paper›PMID 41137660›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Optoacoustic-Guided Magnetic Microrobot Platform for Precision Drug Delivery.

Fan Wang, Erdost Yildiz, Xosé Luís Deán-Ben, Yan Yu, Daniil Nozdriukhin, Wenbin Kang, Shuaizhong Zhang, Jelena Zinnanti, Devin Sheehan, Ren Hao Soon and 3 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fan WangPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Erdost YildizPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID 0000-0001-8086-3524
Xosé Luís Deán-BenInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Zürich, 8093, Switzerland.
Yan YuPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Daniil NozdriukhinInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Zürich, 8093, Switzerland.
Wenbin KangPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Shuaizhong ZhangPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Jelena ZinnantiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Devin SheehanPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Ren Hao SoonPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Shuxin LyuInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Zürich, 8093, Switzerland.
Daniel RazanskyInstitute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Zürich, 8093, Switzerland.
Metin SittiPhysical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.ORCID 0000-0001-8249-3854

Funding

High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin SupplementRF1NS126102 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CAMPBELL, ROBERT E., RAZANSKY, DANIEL · 2022 to 2024
$3.1M
China Scholarship Council 202104910060European Research Council (ERC) Advanced Grant SoMMoR project 834531H2020 Marie Skłodowska-Curie Postdoctoral Fellowship 101059593H2022 Marie Skłodowska-Curie Postdoctoral Fellowship 101109050Max-Planck-Gesellschaft N/ANINDS NIH HHS RF1 NS126102Swiss Cancer Research KFS-5234-02-2021Swiss National Science Foundation 310030_192757US National Institutes of Health RF1-NS126102
6 · The paper itself

Abstract

Precision drug delivery remains a significant challenge due to limitations in drug loading, targeted release, precise navigation, and real-time monitoring. Here, the study reports a magnetic microrobot platform (MMP) that integrates high-capacity drug loading, magnetically actuated collective navigation, controlled drug release, and real-time 3D optoacoustic imaging in a single system. The MMP exploits synergistic advantages by embedding hard-magnetic FePt nanoparticles in a degradable ZIF-8 shell, achieving a drug loading efficiency of ≈93.9% and enabling precise release in response to pH changes and radiofrequency-induced heating. Reconfigurable swarm behavior strategies significantly enhance the navigation efficiency of microrobots against physiological blood flows within complex cerebral vasculature. The ex vivo and in vivo experiments further demonstrate strong contrast characteristics of the microrobots, enabling high-resolution visualization of deep vascular structures and dynamic tracking of MMP with real-time 3D optoacoustic imaging. This multifunctional strategy paves the way for clinical translation and precision therapy in complex biological settings.

Indexed as

Drug Delivery SystemsPhotoacoustic TechniquesRoboticsAnimalsDrug LiberationMicedrug deliverymagnetic nanoparticlesmetal–organic frameworksmicroroboticsoptoacoustic imaging

Identifiers

PMID41137660
PMCPMC12822537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.