Observational studySkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2025
Intravital Visualization of Tattoo Particles After Picosecond Laser Treatment.
Observational study in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06431464 (In Vivo Analysis of Tattoo Particles After Picosecond Laser Compared to Nanosecond Laser), which is not on this map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
In Vivo Analysis of Tattoo Particles After Picosecond Laser Compared to Nanosecond Laser
Who cites it
3 citing papers in PubMed.
- Clinical outcomes of a vacuum-assisted multimodal picosecond tattoo removal protocol: a retrospective case series.Lasers in medical science · 2026Observational
- Comparison of the efficacy and safety of 755-nm picosecond alexandrite laser with diffractive lens array vs. fractional microneedle radiofrequency for the treatment of facial photoaging: a retrospective study.Frontiers in medicine · 2026Article
- Intravital Visualization of Tattoo Particles After Picosecond Laser Treatment.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPicosecond (ps) laser treatments have been widely used for several years to remove unwanted tattoos. It is hypothesized that following the laser-induced fragmentation of tattoo particles, transepidermal clearance occurs as one of the elimination processes alongside with the renewal of the skin. Nevertheless, the precise microscopic details of the tattoo clearance process following laser treatment remain unclear.
objectiveTo analyze the transepidermal clearance of tattoo particles, along with the morphological and metabolic changes in the surrounding tissue, following ps laser treatment. MATERIAL AND
methodsThe study population comprised healthy male and female patients seeking laser-assisted tattoo removal, who were recruited from the Laser Department at the University Medical Center Hamburg-Eppendorf. Each subject underwent a single ps laser treatment session, and follow-up assessments were conducted at 6 and 12 weeks post-treatment using multiphoton tomography with fluorescence lifetime imaging (MPT-FLIM).
resultsThe study included a total of nine participants with eleven tattoos. In untreated skin, the tattoo particles were observed to be confined to the dermis, situated between collagen bundles. Six weeks following treatment, tattoo particles were observed in both inter- and intracellular spaces across all epidermal and the upper dermal layers. By the 12-week follow-up, particles were still present in the epidermis and dermis, although their quantity appeared to have decreased. In accordance with the aforementioned findings, the mean fluorescence lifetime measurements demonstrated a decrease across the follow-up visits, although they remained elevated at 12 weeks.
conclusionOur in vivo, non-invasive imaging data indicate that the transepidermal clearance of tattoo particles following ps laser treatment can extend over several months. This supports the hypothesis that longer intervals between ps laser treatments may be beneficial. Further prospective clinical studies are required to compare the efficacy and safety of short- and long-term treatment intervals in laser-assisted tattoo removal.
trial registrationClinicalTrials.gov identifier: NCT06431464.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.