Evidence map›Paper›PMID 41137588›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Shaping Magnetic Hyperthermia Properties through Nanoparticle Surface-Ligand Design: Implications for Cellular Responses.

Lukas Hertle, Alberto López-Ortega, Hao Ye, Alba Martínez-Jiménez de Allo, Eneko Garaio, Valentin Gantenbein, Joaquim Llacer-Wintle, Ishika Paul, Sarina Nigg, Josep Puigmartí-Luis and 4 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lukas HertleMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Alberto López-OrtegaDepartamento de Ciencias, Campus de Arrosadía, Universidad Pública de Navarra, Pamplona, 31006, Spain.ORCID 0000-0003-3440-4444
Hao YeMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Alba Martínez-Jiménez de AlloDepartamento de Ciencias, Campus de Arrosadía, Universidad Pública de Navarra, Pamplona, 31006, Spain.
Eneko GaraioDepartamento de Ciencias, Campus de Arrosadía, Universidad Pública de Navarra, Pamplona, 31006, Spain.ORCID 0000-0002-3144-7898
Valentin GantenbeinMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Joaquim Llacer-WintleMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Ishika PaulMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Sarina NiggMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Josep Puigmartí-LuisDepartament de Ciència dels Materials i Química Física, Institut de Química Teòrica i Computacional, University of Barcelona, Martí i Franquès, 1, Barcelona, 08028, Spain.ORCID 0000-0002-7510-9815
Marta EstraderDepartment of Inorganic and Organic Chemistry, Inorganic Chemistry Section, University of Barcelona, Carrer de Martí i Franquès, 1-11, Barcelona, 08028, Spain.
Xiang-Zhong ChenInternational Institute of Intelligent Nanorobots and Nanosystems, College of Intelligent Robotics and Advanced Manufacturing, State Key Laboratory of Photovoltaic Science and Technology, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Institute of Optoelectronics, Fudan University, Shanghai, 200433, China.
Bradley J NelsonMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.
Salvador PanéMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zürich, Tannenstrasse 3, Zürich, CH-8092, Switzerland.ORCID 0000-0003-0147-8287

Funding

Agencia Estatal de Investigación (María de Maeztu) CEX2021-001202-MGeneralitat de Catalunya 2021SGR00270Ministerio de Ciencia e Innovacion and European Union NextGenerationEU/PRTR CNS2022-135787(MCIN/AEI/10.13039/501100011033)Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigacion and ESF Investing in your future CNS2024-154589(MICIU/AEI/10.13039/501100011033)Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigacion and ESF Investing in your future PID2019-106165GB-C22(MICIU/AEI/10.13039/501100011033)Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigacion and ESF Investing in your future RYC2018-024396-I(MICIU/AEI/10.13039/501100011033)National Natural Science Foundation of China 52473254Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 190451Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 198643
6 · The paper itself

Abstract

Magnetic iron oxide nanoparticles have attracted increasing attention for their potential use in biomedicine over the last few decades. Their inherent characteristics have enabled novel therapeutic approaches such as magnetic hyperthermia. To maximize the therapeutic efficacy, several research efforts have been focused on the optimization of these nanoparticles in terms of their size, morphology, and crystal structure etc. However, no consensus has been reached regarding the optimal surface design. To gain deeper insight into this complex phenomenon, the influence of a variety of surface ligands on the magnetic, hyperthermic, and colloidal behaviors of the magnetic iron oxide nanoparticles, along with their influence on cellular viability, is investigated. The results revealed that the molecular structure of the ligands, including both the anchoring group and molecular chain, plays a critical role in determining the above-mentioned properties and performance. This work lays the groundwork for surface engineering of magnetic nanoparticles, emphasizing the need to consider the magneto-hyperthermic performance, colloidal stabilities, and the cellular interactions as interconnected factors that critically influence their clinical applicability.

Indexed as

Hyperthermia, InducedMagnetic Iron Oxide NanoparticlesMagnetite NanoparticlesNanoparticlesCell SurvivalHumansLigandsSurface PropertiesLigandsMagnetite Nanoparticlesiron oxideligandsmagnetic hyperthermiamagnetic nanoparticlessurface modification

Identifiers

PMID41137588
PMCPMC12710192

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.