ArticleJournal of clinical and experimental neuropsychology2025
Using neuropsychological test scores to predict beta-amyloid deposition in older adults across the late-life cognitive continuum.
Article in Journal of clinical and experimental neuropsychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.The journal of prevention of Alzheimer's disease · 2026Article
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5 authors.
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Abstract
introductionMany studies have established the relationship between greater burden of beta-amyloid (aβ), a marker of Alzheimer's disease (AD), and poorer neuropsychological performance. However, it is poorly understood whether neuropsychological test scores predict aβ deposition. This study aimed to evaluate the predictive utility of neuropsychological test scores on aβ deposition in a sample of older adults across the late-life cognitive spectrum.
methodOne hundred and sixty-five older adults classified as cognitively intact (
resultsIn a predominantly non-Hispanic White, college-educated sample, HVLT-R Total and Delayed Recall were negatively associated with aβ deposition above and beyond demographic covariates (i.e. age, sex, years of education, estimated premorbid functioning), accounting for 31% and 39% of variance in aβ, respectively (
conclusionCognitive test scores significantly predicted aβ deposition, with memory measures in particular accounting for approximately a third of the variance. These results provide a proof of concept for use of neuropsychological test scores as tools for estimating biomarkers in neurodegenerative disease.
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