ArticleJournal of clinical laboratory analysis2025
Evaluating the "PLT Clumps?" Flag Originating From Different Channels of the Sysmex XN Haematology Analyser: A Method for Rapidly Distinguishing Between Two Preanalytical Factors Affecting PLT Counting for Cancer Patients.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigated the accuracy of the "PLT Clumps?" flag triggered by different channels on the Sysmex XN haematology analyser in identifying two sample states and to optimize the platelet review strategy for cancer patients.
methods570 samples flagged "PLT Clumps?" in CBC + DIFF mode were analysed. After excluding clots, retesting was conducted in CBC + DIFF + PLT-F mode. The accuracy of the "PLT Clumps?" flag and its correlation with PLT aggregation (PA) or fibrin precipitation (FP) were evaluated. Low-platelet count samples were collected for a second blood draw to confirm whether pseudothrombocytopenia (PTCP) was present. The incidence and positive predictive value (PPV) of the "PLT Clumps?" flag across different tumours were also analysed.
resultsAmong 85 verified cases (PA = 17, FP = 63), the overall PPV of the "PLT Clumps?" flag was 14.9% (85/570) in CBC + DIFF mode, 3.5% in WNR channel only, 73.9% in WDF channel only, and 94.4% in dual-channel. In CBC + DIFF + PLT-F mode, the overall PPV and NPV were 98.5% (65/66) and 97.0% (484/499), respectively. PA and FP accounted for 73.9% (17/23) and 26.1% (6/23) of the PLT-F-only flagged samples, respectively, and all WDF-only and dual-flagged cases were triggered by FP. The incidence of PTCP in samples flagged for "PLT Clumps?" in CBC + DIFF + PLT-F mode was 80%. Samples from patients with hepatobiliary tumours showed highest flagging rate (20.4%) but a lower PPV.
conclusionThe correlation between "PLT Clumps?" flags originating from different channels and two common preanalytical factors interfering in PLT counting was analysed, and the platelet review strategy for cancer patients was optimized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.