ArticlePest management science2026
Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide-susceptible and resistant strains.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundResistance to acaricides underscores the need for tick control alternatives. We previously identified in a high-throughput screen six small molecules SACC-0412060, SACC-0412062, SACC-0412066, SACC-0064443, SACC-0428788, and SACC-0039590 as antagonists of the kinin receptor from Rhipicephalus microplus. The acaricidal activity of these molecules was investigated.
resultsThe toxicities of adjuvant/solvent combinations of a rapeseed oil methyl ester or a propylene carbonate in 5% DMSO versus 5% DMSO alone were evaluated using a larval immersion test (LIT) with the R. microplus susceptible Deutch strain, and all were non-toxic. The rapeseed oil methyl ester (1%) in 5% DMSO was adopted as the adjuvant for all molecules in bioassays. Permethrin (3.19 mM) killed all larvae. The Deutch strain mortality with SACC-0039590 and SACC-0428788 (both at 1 mM) was 100% and 73.65%, respectively, while ranged from 2.7% to 3.8% with the other small molecules. In the LIT, the LC
conclusionThe small molecule SACC-0039590 killed susceptible and pyrethroid-resistant larvae of R. microplus and reduced the reproductive output of females. © 2025 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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