ArticleAdvanced healthcare materials2026
Strontium-Containing Bioactive Glass Nanoparticles Stimulate Osteogenesis and Suppress Osteoclast Formation in Co-Culture.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Strontium-Containing Bioactive Glass Nanoparticles Stimulate Osteogenesis and Suppress Osteoclast Formation in Co-Culture.Advanced healthcare materials · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
The effect of monodispersed bioactive glass nanoparticles containing strontium (9.4 mol % SrO and 4.4 mol% SrO) and their dissolution products on osteoclast differentiation are investigated in monoculture and in an osteoblast-osteoclast in vitro co-culture system. Under standard conditions, RAW264.7 cells efficiently differentiate into osteoclast-like cells upon RANKL stimulation, making them a well-established monoculture model for osteoclastogenesis. The viability of RAW264.7 cells exposed to nanoparticles is dose- and time-dependent. Indirect co-culture of pre-osteoblast MC3T3-E1 and mouse monocyte RAW264.7 cells is carried out using Millipore cell culture plate inserts, with and without RANKL. Osteoclast differentiation, indicated by tartrate-resistant acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts, is significantly reduced in RAW264.7 cells exposed to Sr-BGNPs and their dissolution products, compared to RANKL-stimulated control cells. Therefore, the observed reduction in osteoclast differentiation following exposure to Sr-BGNPs and their ionic dissolution products indicates a potential inhibitory effect on this process. In co-culture, bioactive glass nanoparticles containing 9.4 mol% SrO
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Registered trials
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