Evidence map›Paper›PMID 41137430›Full record

ArticleChemistryOpen2026

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis.

João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José Dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antibiotics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

João Arthur de Oliveira BorgesLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.
Priscilla Ramos FreitasLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.
Isaac Moura AraújoLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.
Ray Silva de AlmeidaLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.
Igor José Dos Santos NascimentoLaboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil.
João Xavier de Araújo-JúniorLaboratory of Medicinal Chemistry, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil.
Edeildo Ferreira da Silva-JúniorBiological and Molecular Chemistry Research Group, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil.
Thiago Mendonça de AquinoLaboratory of Synthesis and Research in Medicinal Chemistry, Research Group on Therapeutic Strategies-GPET, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, AL, 57072-900, Brazil.
Francisco Jaime Bezerra Mendonça JuniorDepartment of Biological Science, Laboratory of Synthesis and Drug Delivery-LSVM, State University of Paraiba, João Pessoa, 58071-160, PB, Brazil.
Emmanuel Silva MarinhoLaboratory of Chemistry of Natural and Synthetic Product, State University of Ceara´, UECE, Fortaleza, Ceara´, 60714-903, Brazil.
Hélcio Silva Dos SantosLaboratory of Chemistry of Natural and Synthetic Product, State University of Ceara´, UECE, Fortaleza, Ceara´, 60714-903, Brazil.
Radosław KowalskiUniversity of Life Sciences in Lublin, 20-950, Lublin, Poland.
Grażyna KowalskaUniversity of Life Sciences in Lublin, 20-950, Lublin, Poland.
Henrique Douglas Melo CoutinhoLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.ORCID 0000-0002-6634-4207
Saulo Relison TintinoLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.
Ana Carolina Justino de AraújoLaboratory of Microbiology and Molecular Biology-LMBM, Regional University of Cariri, Crato, CE, 63105-000, Brazil.

Funding

CAPESCNPqFINEPFUNCAP
6 · The paper itself

Abstract

The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of conventional treatments. In this context, thiadiazines have emerged as promising agents due to their antioxidant and antibacterial properties. This article aims to evaluate the antibacterial potential of synthetic thiadiazine analogs against selected bacterial strains. The synthesized compounds are purified using high-performance liquid chromatography, and absorption, distribution, metabolism, excretion, and toxicity analyses are performed, including interaction profiling with over 370,000 bioactive compounds. The bacterial strains Staphylococcus aureus 10 and Pseudomonas aeruginosa 24 are used as test organisms. When combined with standard antibiotics, thiadiazine compounds significantly reduced the minimum inhibitory concentration. However, some analogs exhibited antagonistic effects, particularly against gentamicin and erythromycin. Direct antibacterial activity is limited, with compounds IJ26 and IJ28 showing the most notable effects. These findings suggest that thiadiazine analogs may potentiate antibiotic activity, although further studies are needed to fully understand their biological interactions and mechanisms of action.

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialPseudomonas aeruginosaStaphylococcus aureusThiadiazinesMicrobial Sensitivity TestsAnti-Bacterial AgentsThiadiazinesbacterial resistancebiological interactionsmacromoleculesPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID41137430
PMCPMC13052028

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.