Evidence map›Paper›PMID 41137388›Full record

ReviewBiophysical journal2026

Advances of 3D microcrystals electron diffraction for transmembrane protein structure determination.

Giorgia Fiorini, Gebhard F X Schertler, Valérie Panneels

Abstract readReview
In one paragraph

Review in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Electrons and X-rays for diffraction and imaging.Acta crystallographica. Section D, Structural biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giorgia FioriniDivision of Biology and Chemistry, Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen PSI, Switzerland. Electronic address: giorgia.fiorini@psi.ch.
Gebhard F X SchertlerDivision of Biology and Chemistry, Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen PSI, Switzerland.
Valérie PanneelsDivision of Biology and Chemistry, Laboratory for Biomolecular Research, Paul Scherrer Institute, Villigen PSI, Switzerland. Electronic address: valerie.panneels@psi.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electron diffraction of 3D microcrystals (3D ED/MicroED) is an emerging technique that uses electrons to determine proteins structure from their nano-sized 3D crystals, thus overcoming the limitations on crystal-size dimensions generally imposed by x-ray or neutron diffraction. The strong interactions of electrons with matter have the potential to reveal the location of light atoms (e.g., hydrogens), revealing interaction networks, and to provide information about the charge states of the atoms. Recent advances in MicroED sample preparation and data collection strategies have led to structural determination of several known and unknown protein structures, including challenging targets such as membrane proteins. In this review, we provide an overview of the recent advances of MicroED including sample preparation and data collection.

Indexed as

ElectronsMembrane ProteinsProtein ConformationMembrane Proteins

Identifiers

PMID41137388
PMCPMC13351544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.