Evidence map›Paper›PMID 41137175›Full record

Observational studyParasites & vectors2025

Tick-borne lymphadenopathy in northeastern France: a human and vector clinical-epidemiological study.

Jeanne Kotzyba, Elisabeth Baux, Yves Hansmann, Pierre Boyer, Benoît Jaulhac, Martin Martinot, Benoît Martha, Charlotte Kaeuffer, Thomas Bonijoly, Firouzé Bani-Sadr and 7 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jeanne KotzybaUniversity of Lorraine, University Hospital of Nancy, Nancy, France. j.kotzyba@chru-nancy.fr.
Elisabeth BauxTick Borne Disease Reference Center of Northeastern Region, University Hospital of Nancy, Nancy, France.
Yves HansmannTick Borne Disease Reference Center of Northeastern Region, University Hospital of Strasbourg, Strasbourg, France.
Pierre BoyerUR3073: PHAVI: Group Borrelia, National Reference Center for Borrelia, University of Strasbourg, Strasbourg, France.
Benoît JaulhacUR3073: PHAVI: Group Borrelia, National Reference Center for Borrelia, University of Strasbourg, Strasbourg, France.
Martin MartinotHospital of Colmar, Colmar, France.
Benoît MarthaHospital of Chalon-Sur-Saône, Chalon-Sur-Saône, France.
Charlotte KaeufferHospital of Mulhouse, Mulhouse, France.
Thomas BonijolyHospital of Sélestat, Sélestat, France.
Firouzé Bani-SadrUniversity Hospital of Reims, Reims, France.
Antoine LegoffMetz Private Hospital Group, Metz, France.
Florence HoeflerHospital of Troyes, Troyes, France.
Mathieu BlotUniversity Hospital of Dijon-Bourgogne, Dijon, France.
Loïc BourdellonHospital Center of Epinal, Epinal, France.
Laurence ZillioxUR3073: PHAVI: Group Borrelia, National Reference Center for Borrelia, University of Strasbourg, Strasbourg, France.
Nathalie BoulangerUR3073: PHAVI: Group Borrelia, National Reference Center for Borrelia, University of Strasbourg, Strasbourg, France.
Benjamin LefevreInserm, INSPIIRE, University Hospital of Nancy, University of Lorraine, Nancy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTick-borne lymphadenopathy (TIBOLA) is a tick-borne disease transmitted by Dermacentor ticks and is usually caused by Rickettsia. In 2021, clinicians in northeastern France reported an increase in TIBOLA cases.

methodsThis entomo-clinical, multicenter, retrospective, and observational study aimed to describe the evolution of the number of TIBOLA cases between 2016 and 2021 in northeastern France as well as the evolution of the Dermacentor tick population.

resultsA total of 35 cases of TIBOLA were identified, 16 of which occurred in 2021, with clear predominance in April and May. A longitudinal study performed in the Alsace region (endemic for ticks and tick-borne diseases) revealed a peak in tick activity in 2021. A trend toward an increase in TIBOLA cases in 2021 in the northeastern region of France was observed, as was an increase in the Dermacentor tick population in some biotopes.

conclusionsTIBOLA appears to be an emerging disease that should be monitored, as should the Dermacentor population.

Indexed as

DermacentorLymphadenopathyRickettsia InfectionsTick-Borne DiseasesAdolescentAdultAgedAnimalsArachnid VectorsFemaleFranceHumansLongitudinal StudiesMaleMiddle AgedRetrospective StudiesDEBONELDermacentorInoculation escharRickettsiosisSENLATTIBOLATick-borne disease

Identifiers

PMID41137175
PMCPMC12551298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.