Evidence map›Paper›PMID 41137159›Full record

ArticleGenome biology2025

Unlocking the regulatory code of RNA: launching the Human RNome Project.

International Human RNome Project Consortium

Abstract read
In one paragraph

Article in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Epitranscriptomic Analysis of A-to-I RNA Editing and mInternational journal of molecular sciences · 2026
    Review
  3. The impact of psuedouridine modification on human tRNA.Biochemical Society transactions · 2026
    Review
  4. Chalcogen-modified Nucleic Acid Analogues.Current medicinal chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

International Human RNome Project Consortium

Funding

Technology Development Coordinating CenterU24HG011735 · NHGRI · JACKSON LABORATORY · PI Mark D ADAMS · 2021 to 2026
$8.1M
Austrian Science Fund 10.55776/F80NHGRI NIH HHS U24 HG011735NIH HHS ES031576NIH HHS ES034919NIH HHS U24HG011735PRC epiRNA-T2D ANR-23-CE14-0040PRC IDyL ANR 24-CE17-7018
6 · The paper itself

Abstract

The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucleotide residues, the RNome, encompassing over 180 distinct modifications across organisms, with at least 50 in humans, is increasingly recognized. These modifications play critical roles in regulating RNA structure, stability, and function, yet the rules linking their precise locations to biological outcomes remain poorly defined. The Human RNome Project aims to map all RNA modifications, build essential resources, and harness new technologies to transform RNA biology, therapeutic development, agriculture, and even data storage.

Indexed as

RNARNA Processing, Post-TranscriptionalHumansRNA

Identifiers

PMID41137159
PMCPMC12551254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.