ArticleBMC sports science, medicine & rehabilitation2025
"Hybrid exercise training improves liver steatosis and inflammation in a randomized trial of sedentary, obese women with non-alcoholic fatty liver disease".
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05231564 (Study of Hybrid Training on Lipid Profile and Non-alcoholic Fatty Liver Disease in Middle-aged Obese Women), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Hybrid Training on Lipid Profile and Non-alcoholic Fatty Liver Disease in Middle-aged Obese Women
Who cites it
1 citing paper in PubMed.
- Evidence Summary for Self-Management Education in Patients with Non-Alcoholic Fatty Liver Disease.Patient preference and adherence · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-alcoholic fatty liver disease (NAFLD) represents a significant and escalating public health challenge, particularly in obese, sedentary populations. Hybrid exercise training, integrating electrical muscle stimulation (EMS) with voluntary muscle contractions, offers a novel, low-impact therapeutic modality; however, its clinical efficacy remains underexplored.
objectivesThis randomized controlled trial investigated the clinical efficacy of hybrid exercise training in improving hepatic steatosis, liver enzyme profiles, systemic inflammation, and metabolic health in sedentary, obese, middle-aged women with NAFLD.
methodsThirty women with ultrasound-confirmed grade 2-3 NAFLD were randomized to either six weeks of hybrid exercise training (n = 15) or lifestyle counseling (n = 15). Primary and secondary outcomes included liver steatosis grade, serum liver enzymes (AST, ALT), inflammatory marker IL-6, fasting blood glucose, and anthropometric parameters.
resultsHybrid exercise training led to significant improvements compared with lifestyle counseling. Steatosis grade decreased markedly (- 0.80 vs. -0.02; p < 0.01; η² = 0.38), accompanied by large reductions in ALT (- 31.86 U/L; p < 0.01; η² = 0.65) and AST (- 27.46 U/L; p < 0.01; η² = 0.61). IL-6 concentrations declined (- 3.0 pg/mL; p < 0.05; η² = 0.42), while anthropometric outcomes improved (body weight - 4.51 kg, BMI - 1.56 kg/m², WHR - 0.042; all p < 0.01; η² ≥ 0.52). Correlation analyses showed that decreases in IL-6 were strongly associated with improvements in ALT (r = - 0.72, p < 0.01) and AST (r = - 0.68, p < 0.01).
conclusionsHybrid exercise training is a safe, feasible, and clinically effective intervention for improving liver health and attenuating systemic inflammation in obese women with NAFLD, with strong associations between IL-6 reductions and liver enzyme improvements. CLINICAL
trial registrationClinicalTrials.gov, NCT05231564, Registered on 28 February 2022.
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