Evidence map›Paper›PMID 41136990›Full record

ArticleBMC infectious diseases2025

Correlation analysis between positivity rate of immunoglobulin G antibodies against pertussis toxin among community-based populations and reported pertussis incidence in Shandong, China: a seven-year seroepidemiological study.

Yan Zhang, Manshi Li, Lei Feng, Zexin Tao, Xinyu Yuan, Guifang Liu, Aiqiang Xu, Li Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan ZhangDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Manshi LiDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Lei FengDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Zexin TaoDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Xinyu YuanDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Guifang LiuDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Aiqiang XuDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China.
Li ZhangDivision of Expanded Immunization Program, Shandong Provincial Center for Disease Control and Prevention, Shandong Academy of Preventive Medicine, Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, No. 16992 Jingshi Road, Jinan, 250014, P. R. China. ZL9127@163.com.

Funding

Taishan Scholar Program of Shandong Province Tstp20221164 and ts201511105
6 · The paper itself

Abstract

backgroundThe reported annual incidence of pertussis in China has shown a marked increase over the past decade, but it may be still underestimated. The purpose of this study was to understand the seroepidemiologic characteristics of pertussis in community-based populations and to assess the level of pertussis infection in the population.

methodsBetween 2017 and 2023, one or two cities in each of the eastern, central and western regions of Shandong Province were selected as survey sites, and a total of six age groups of healthy individuals were enrolled by multistage stratified random sampling to carry out the survey. The serum level of pertussis toxin (PT) IgG antibody was quantified by indirect enzyme-linked immunosorbent assay.

resultsA total of 9,238 subjects were enrolled, and the mean positive rate of PT-IgG antibody was 8.05% (95%CI: 7.50%~8.60%), with the highest in 2019 (10.70%, 95% CI: 9.19%~12.21%) and the lowest in 2020 (6.32%, 95% CI: 4.98%~7.66%). The highest positive rate was found in the age group of less than 3 years old (11.46%, 95%CI: 9.87%~13.05%), and the lowest rate was found in the 3 ~ 5 years group (5.40%, 95%CI: 4.28%~6.52%). There was a significant difference in the positive rate between age groups (χ

conclusionsThe annual distribution trend of reported pertussis incidence rate aligns with the infection rate observed among community populations, the actual level of infection is likely to be seriously underestimated. Therefore there is a need to emphasize surveillance and consider additional booster immunizations for adolescents and adults.

Indexed as

Antibodies, BacterialImmunoglobulin GPertussis ToxinWhooping CoughAdolescentAdultAgedChildChild, PreschoolChinaFemaleHumansIncidenceInfantInfant, NewbornMaleAntibodies, BacterialImmunoglobulin GPertussis ToxinAntibodies against pertussis toxinEstimated infection ratePertussisSeroepidemiology

Identifiers

PMID41136990
PMCPMC12551178

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.