ArticleBMC pregnancy and childbirth2025
Evaluation of cardiac strain parameters in pregnant women with and without iron deficiency anemia: a prospective case control study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Correlation of anemia severity with maternal cardiac function during third trimester - An observational study.Bioinformation · 2026Article
- Ethnic Variation in Left Ventricular Size and Mechanics During Healthy Pregnancy: A Systematic Review of Asian and Western Cohorts.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron deficiency anemia (IDA) is highly prevalent in pregnancy and may impair cardiovascular function. Strain echocardiography can detect subclinical myocardial dysfunction, yet data on strain alterations in pregnant women with IDA are limited.
methodsThis prospective comparative study included 80 pregnant women in the second or third trimester: 40 with IDA and 40 without anemia. All participants underwent comprehensive echocardiographic evaluation, including left ventricular global longitudinal strain (LV GLS) and right ventricular strain parameters. Laboratory iron indices were also assessed.
resultsLV GLS was significantly reduced in the IDA group compared with controls (- 17.46 ± 2.14% vs. -19.34 ± 2.74%, p = 0.001). Basal right ventricular free-wall strain was more negative in the IDA group (p = 0.032), and systolic pulmonary artery pressure was higher (p = 0.005). ROC analysis identified an LV GLS cut-off of - 20.55% for detecting subclinical cardiac dysfunction (AUC = 0.699, sensitivity = 90.0%, specificity = 70.0%). Iron indices showed significant correlations with multiple strain parameters.
conclusionsIDA in pregnancy is associated with subclinical alterations in left and right ventricular strain despite preserved ejection fraction. Strain echocardiography may be a valuable tool for early detection of cardiac involvement in anemic pregnant women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.