ArticleBMC cardiovascular disorders2025
Relationship between monocyte-to-HDL-cholesterol ratio, estradiol levels, and coronary atherosclerosis severity in postmenopausal women.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Mechanistic Insights into Therapeutic Strategies for Post- Menopausal Atherosclerosis: Evidence from an Ovariectomized Mouse Model.Journal of cardiovascular translational research · 2026Review
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5 authors.
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Abstract
backgroundCoronary atherosclerosis is a leading cause of coronary heart disease (CHD), particularly among postmenopausal women who experience significant hormonal changes that influence lipid metabolism and inflammatory processes. We aimed to investigate the correlation between monocyte-to-HDL-cholesterol ratio (MHR), estradiol and the severity of coronary lesions in postmenopausal patients with CHD.
methodsThis study included 360 postmenopausal women diagnosed with CHD. The Gensini score (GS) was obtained from coronary angiography, and patients were divided into three groups according to the severity of coronary lesions assessed by GS - patients with mild coronary lesions (Gensini score < 20), patients with moderate coronary lesions (20 ≤ Gensini score < 40) and patients with severe coronary lesions (Gensini score ≥ 40). We used ordinal logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between estradiol, MHR, and coronary lesion severity. For assessing the value of estradiol and MHR in predicting the severity of CHD, we adopted the generalized area under the receiver operating characteristic (ROC) curve method.
resultsThe severe lesion group had the lowest estradiol levels and the highest MHR (all p < 0.001). MHR showed a weaker negative correlation with estradiol levels. After adjusting for confounding factors, estradiol was significantly negatively correlated with the severity of CHD (OR = 0.93, 95%CI = 0.91-0.96), while MHR was significantly positively correlated with the severity of CHD (OR = 1.15, 95%CI = 1.01-1.29). Interaction analysis showed significant interaction between estradiol levels and MHR (p < 0.001). The area under the curve (AUC) of MHR and estradiol in predicting the severity of CHD in postmenopausal women for the ROC analysis was 0.806 (95%CI = 0.745-0.866) and 0.661 (95%CI = 0.592-0.730), respectively. The AUC of MHR combined with estradiol was 0.826 (95%CI = 0.774-0.877).
conclusionBoth estradiol and MHR are independently correlated with and can be used to predict the severity of CHD in postmenopausal women. The combination of estradiol and MHR has a higher predictive value for the severity of CHD. CLINICAL TRIAL NUMBE: Not applicable.
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