Evidence map›Paper›PMID 41136906›Full record

Trial reportBMC microbiology2025

Oral microbiome dynamics in head and neck cancer patients undergoing oral healthcare: implications for prognosis and early diagnosis.

Xiaoqin Ji, Yixin Qiao, Jiqiu Wu, Weili Kong, Rong Yu, Xiuli Yang, Xin Deng, Haopeng Yu, Huiling Zhao

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoqin Ji *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China.
Yixin Qiao *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Road, Sichuan Province, 610041, Chengdu, China.
Jiqiu WuWest China Biomedical Big Data Center, West China Hospital, Med-X Center for Informatics, Sichuan University, No. 37 Guoxue Road, Sichuan Province, 610041, Chengdu, China.
Weili KongDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Road, Sichuan Province, 610041, Chengdu, China.
Rong YuDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China.
Xiuli YangDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China.
Xin DengDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China.
Haopeng YuWest China Biomedical Big Data Center, West China Hospital, Med-X Center for Informatics, Sichuan University, No. 37 Guoxue Road, Sichuan Province, 610041, Chengdu, China.
Huiling ZhaoDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan Province, 610041, China. 15710087@163.com.

Funding

The Science and Technology Department of Sichuan Province 2021YFS0156
6 · The paper itself

Abstract

backgroundPostoperative head and neck cancer (HNC) patients frequently experience oral microbiome dysbiosis and bad prognosis outcomes due to surgical trauma and reduced oral function, which may exacerbate symptoms and impair recovery. This study investigates how two oral mouthwash interventions—normal saline (N) and Yikou gargle (Y)—influence the oral microbiome at critical postoperative time points and explores their prognostic implications.

methodsEighty HNC patients scheduled for surgery (30 requiring tracheostomy) were randomized into Group N or Group Y. Saliva samples were collected at baseline, post-operation, and pre-discharge. Using 16 S rRNA sequencing, we analyzed microbiome composition, compared community diversity, identified intervention-enriched taxa, and evaluated the clinical prognostic effects, such as dental issues.

resultsWhile both groups initially exhibited comparable microbiome diversity, Group Y demonstrated pronounced clustering distinct from the Group N. Streptococcus dominated both cohorts, but the Group Y exhibited reduced abundance of pathobionts, such as Haemophilus (LDA > 2, p < 0.05 ). Clinically, tracheostomy patients in Group Y reported reduced severity of dental complications (p = 0.019) and higher abundance of Abiotrophia (p = 0.003) compared to Group N counterparts.

conclusionOur study provides insights into the impact of oral mouthwash interventions on the oral microbiome dynamics of HNC patients and their potential implications for prognosis. Understanding the role of the oral microbiome in HNC may pave the way for innovative therapeutic strategies that target the oral microbiota to improve treatment outcomes.

Indexed as

BacteriaHead and Neck NeoplasmsMicrobiotaMouthMouthwashesAdultAgedDysbiosisFemaleHumansMaleMiddle AgedPrognosisRNA, Ribosomal, 16SSalivaMouthwashesRNA, Ribosomal, 16SChlorhexidine.Head and neck cancerNormal salineOral microbiotaOral mouthwash

Identifiers

PMID41136906
PMCPMC12551258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.