ArticleCurrent microbiology2025
Regional Genomic and Phylogenomic Insights into Multidrug and Colistin-Resistant Klebsiella pneumoniae Strains from Tanzania, Kenya, Uganda, and Ethiopia.
Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lytic bacteriophages targeting carbapenem-resistant Klebsiella pneumoniae isolated in a resource-limited Zambian laboratory.Access microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae (K. pneumoniae) is one of the notorious pathogens with rapidly evolving antimicrobial resistance (AMR) globally. With an unpredictable trend of AMR, colistin is the last resort antibiotic, but its resistance pattern in sub-Saharan Africa is comparatively unknown, hampering the prediction of international transmission. Here, we aimed to dissect a comparative AMR among strains isolated from Tanzania, Kenya, Uganda, and Ethiopia and to obtain a snapshot of versatility in colistin resistance. We retrieved whole genome sequence datasets and performed single nucleotide polymorphism (SNP) analysis along with comparative AMR analysis using ResFinder and Comprehensive Antibiotic Resistance Database (CARD to obtain genes and mutations related to AMR. Further, we performed Multilocus sequence typing (MLST) to unveil lineages and plasmids critical for AMR. Our results uncovered widespread resistance to fluoroquinolones, β-lactams, and aminoglycosides with diverse plasmid-mediated resistance mechanisms. Colistin resistance is largely determined by nonsynonymous SNPs of genes arn, pmrA/B, pagP, and eptA/B across the countries. Importantly, we found two Kenyan strains carrying the mcr-8.1 gene conferring colistin resistance. All the countries possess MDR strains, with Kenya emerging as the leading and the only country harboring mcr genes so far. The detection of chromosomal and plasmid-borne colistin resistance, including mcr-8.1 on IncR plasmids, underscores a critical threat to last-line antibiotics. Taken together, our findings underscore a potential risk of the evolution of colistin-resistant K. pneumoniae strains with resistance mechanisms integrating mcr and chromosomal lipid A-modifying enzymes, highlighting the urgent need for surveillance and antimicrobial stewardship revisits across the region.
Indexed as
Identifiers
41136822What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.