Evidence map›Paper›PMID 41136720›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Curcumin alleviates ferroptosis in CCl₄-induced acute liver injury in vitro: involvement of TXNIP/NLRP3 inhibition and SLC7A11/GSH/GPX4 activation.

Wei Zhang, Ziqi Liu, Changle Dong, Huimin Yang, Yunchao Zhang, Shuo Li, Yinsheng Qiu, Lingyun Xu

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Zhang *School of Life Science and Technology, Wuhan Polytechnic University, Xuefu South Road 68, Changqing Garden, Wuhan, 430023, China.
Ziqi Liu *School of Life Science and Technology, Wuhan Polytechnic University, Xuefu South Road 68, Changqing Garden, Wuhan, 430023, China.
Changle Dong *School of Life Science and Technology, Wuhan Polytechnic University, Xuefu South Road 68, Changqing Garden, Wuhan, 430023, China.
Huimin YangSchool of Life Science and Technology, Wuhan Polytechnic University, Xuefu South Road 68, Changqing Garden, Wuhan, 430023, China.
Yunchao ZhangCollege of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China.
Shuo LiHVSEN Biotechnology Co., Ltd, Wuhan, 430042, China.
Yinsheng QiuSchool of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan, 430023, China.
Lingyun XuSchool of Life Science and Technology, Wuhan Polytechnic University, Xuefu South Road 68, Changqing Garden, Wuhan, 430023, China. xly9898@whpu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver injury (ALI) is a global health issue associated with high mortality rates and has garnered significant clinical attention. Curcumin (CUR), a natural compound derived from turmeric rhizomes, possesses diverse therapeutic benefits. This article examines the mechanism by which CUR intervenes in ALI induced by carbon tetrachloride (CCl

Indexed as

Carrier ProteinsChemical and Drug Induced Liver InjuryCurcuminFerroptosisNLR Family, Pyrin Domain-Containing 3 ProteinAmino Acid Transport System y+Carbon TetrachlorideGlutathioneHep G2 CellsHumansInflammasomesPhospholipid Hydroperoxide Glutathione PeroxidaseThioredoxinsAmino Acid Transport System y+Carbon TetrachlorideCarrier ProteinsCurcuminGlutathioneInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPhospholipid Hydroperoxide Glutathione PeroxidaseThioredoxinsTXNIP protein, humanCarbon tetrachlorideCurcuminFerroptosisSLC7A11/GSH/GPX4TXNIP/NLRP3

Identifiers

PMID41136720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.