Observational studyPediatric research2026
Pediatric respiratory co-infection and immunologic response: peds recon study protocol.
Observational study in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comparing in-person and online recruitment methods in a prospective pediatric cohort study.Pediatric research · 2026Article
- Genomic Surveillance of Endemic Human Coronaviruses in Côte d'Ivoire Using Targeted Hybrid-Capture Sequencing.Viruses · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute Viral Respiratory Infections (AVRIs) from SARS-CoV-2, influenza, and RSV are major causes of pediatric illness, yet little is known about how non-medically attended infections influence immune development. Understanding early-life AVRIs patterns and their impact on the developing mucosal immune system is essential to inform interventions that improve long-term child health.
methodsThis ongoing prospective observational cohort study, initiated in January 2024, investigates respiratory viral infections, co-infections, and their effects on immune responses in children aged 1 month to 17 years. Participants are followed for two years, with data collected at baseline (when healthy) and during acute visits (when symptomatic). At baseline, nasopharyngeal swabs and blood samples are collected for viral screening and immune analysis. During acute visits, swabs are collected for viral detection and immunologic assays. If SARS-CoV-2, influenza, or RSV is detected, a post-acute visit occurs 10-21 days after symptom onset for repeat swabs and blood collection. The primary outcome is to define age-based immune responses and assess how co-infections influence immune regulation. DISCUSSION: This study captures the full spectrum of pediatric AVRIs, including non-medically attended illnesses, to address gaps in immune development research. Findings may inform strategies to optimize prevention and treatment across childhood. IMPACT: Acute viral respiratory infections are the most common cause of childhood morbidity and mortality; however, they are frequently non-medically attended, leaving critical gaps in our understanding. Co-infections with respiratory viruses such as SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) may alter immune responses, but their impact on long-term immunity remains poorly understood. Understanding age-dependent patterns of respiratory viral infections and co-infections will provide critical insights into immune development and potential vulnerabilities in pediatric populations. This study aims to define age-based differences in immunity in the respiratory track in response to respiratory viral pathogens and examine the impact of co-infection on immune regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.